6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide

C137H128F26N24O15S6 — CID 159875955

About 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide

6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide (PubChem CID 159875955) has the molecular formula C137H128F26N24O15S6 and a molecular weight of 3037.03 g/mol. Its IUPAC name is 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide.

Molecular Properties

• Compound Name: 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide
• PubChem CID: 159875955
• Molecular Formula: C137H128F26N24O15S6
• Molecular Weight: 3037.03 g/mol
• Exact Mass: 3034.79
• IUPAC Name: 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide
• SMILES: C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(O)cc3n2C2CCCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(OC(F)F)cc3n2C2CCCC2)nc1)C(F)(F)F.Cc1c(F)cc2c(C#N)c(-c3ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn3)n(C3CCC3)c2c1F.Cc1ccc2c(C#N)c(-c3ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn3)n(C3CCC3)c2c1F.Cc1ccc2c(C#N)c(-c3ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn3)n(C3CCCC3)c2c1F.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCCC2)c2cc(O)c(F)cc12
• InChI: InChI=1S/C24H24F4N4O2S.C23H20F6N4O3S.C23H21F5N4O2S.C23H22F4N4O2S.C22H20F4N4O3S.C22H21F3N4O3S/c1-14-8-10-17-18(12-29)21(32(22(17)20(14)25)15-6-4-5-7-15)19-11-9-16(13-30-19)35(33,34)31-23(2,3)24(26,27)28;1-12(23(27,28)29)32-37(34,35)14-6-7-18(31-11-14)21-16(10-30)15-8-17(24)20(36-22(25)26)9-19(15)33(21)13-4-2-3-5-13;1-12-17(24)9-15-16(10-29)20(32(13-5-4-6-13)21(15)19(12)25)18-8-7-14(11-30-18)35(33,34)31-22(2,3)23(26,27)28;1-13-7-9-16-17(11-28)20(31(14-5-4-6-14)21(16)19(13)24)18-10-8-15(12-29-18)34(32,33)30-22(2,3)23(25,26)27;1-12(22(24,25)26)29-34(32,33)14-6-7-18(28-11-14)21-16(10-27)15-8-17(23)20(31)9-19(15)30(21)13-4-2-3-5-13;23-9-13(10-24)28-33(31,32)15-5-6-19(27-12-15)22-17(11-26)16-7-18(25)21(30)8-20(16)29(22)14-3-1-2-4-14/h8-11,13,15,31H,4-7H2,1-3H3;6-9,11-13,22,32H,2-5H2,1H3;7-9,11,13,31H,4-6H2,1-3H3;7-10,12,14,30H,4-6H2,1-3H3;6-9,11-13,29,31H,2-5H2,1H3;5-8,12-14,28,30H,1-4,9-10H2/t;12-;;;12-;/m.0..0./s1
• InChIKey: NSXHDNBPAGUJMV-WSNSWXSFSA-N
• XLogP: 31.17
• TPSA: 576.37 Ų
• H-Bond Donors: 8
• H-Bond Acceptors: 33
• Rotatable Bonds: 34
• Heavy Atoms: 208
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	3037.03
LogP ≤ 5	31.17
H-Bond Donors ≤ 5	8
H-Bond Acceptors ≤ 10	33

Frequently Asked Questions

What is the IUPAC name of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

The IUPAC name of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide (CID 159875955) is 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide.

What is the SMILES notation for 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

The canonical SMILES for 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide is C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(O)cc3n2C2CCCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(F)c(OC(F)F)cc3n2C2CCCC2)nc1)C(F)(F)F.Cc1c(F)cc2c(C#N)c(-c3ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn3)n(C3CCC3)c2c1F.Cc1ccc2c(C#N)c(-c3ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn3)n(C3CCC3)c2c1F.Cc1ccc2c(C#N)c(-c3ccc(S(=O)(=O)NC(C)(C)C(F)(F)F)cn3)n(C3CCCC3)c2c1F.N#Cc1c(-c2ccc(S(=O)(=O)NC(CF)CF)cn2)n(C2CCCC2)c2cc(O)c(F)cc12.

What is the InChIKey of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

The InChIKey is NSXHDNBPAGUJMV-WSNSWXSFSA-N. The full InChI is InChI=1S/C24H24F4N4O2S.C23H20F6N4O3S.C23H21F5N4O2S.C23H22F4N4O2S.C22H20F4N4O3S.C22H21F3N4O3S/c1-14-8-10-17-18(12-29)21(32(22(17)20(14)25)15-6-4-5-7-15)19-11-9-16(13-30-19)35(33,34)31-23(2,3)24(26,27)28;1-12(23(27,28)29)32-37(34,35)14-6-7-18(31-11-14)21-16(10-30)15-8-17(24)20(36-22(25)26)9-19(15)33(21)13-4-2-3-5-13;1-12-17(24)9-15-16(10-29)20(32(13-5-4-6-13)21(15)19(12)25)18-8-7-14(11-30-18)35(33,34)31-22(2,3)23(26,27)28;1-13-7-9-16-17(11-28)20(31(14-5-4-6-14)21(16)19(13)24)18-10-8-15(12-29-18)34(32,33)30-22(2,3)23(25,26)27;1-12(22(24,25)26)29-34(32,33)14-6-7-18(28-11-14)21-16(10-27)15-8-17(23)20(31)9-19(15)30(21)13-4-2-3-5-13;23-9-13(10-24)28-33(31,32)15-5-6-19(27-12-15)22-17(11-26)16-7-18(25)21(30)8-20(16)29(22)14-3-1-2-4-14/h8-11,13,15,31H,4-7H2,1-3H3;6-9,11-13,22,32H,2-5H2,1H3;7-9,11,13,31H,4-6H2,1-3H3;7-10,12,14,30H,4-6H2,1-3H3;6-9,11-13,29,31H,2-5H2,1H3;5-8,12-14,28,30H,1-4,9-10H2/t;12-;;;12-;/m.0..0./s1.

What are the key properties of 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide?

6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide has a molecular weight of 3037.03 g/mol, XLogP of 31.17, 34 rotatable bonds, 8 hydrogen bond donors, and 33 hydrogen bond acceptors.

Where does this data come from?

All data for 6-(3-cyano-1-cyclobutyl-5,7-difluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide;6-[3-cyano-1-cyclopentyl-6-(difluoromethoxy)-5-fluoroindol-2-yl]-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-5-fluoro-6-hydroxyindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;6-(3-cyano-1-cyclopentyl-7-fluoro-6-methylindol-2-yl)-N-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine-3-sulfonamide is sourced from PubChem (CID 159875955), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).