Chlorothiazide

Thiazide Diuretic — CARDIOVASCULAR SYSTEM

Key facts

Chlorothiazide is an ofp drug in the Thiazide Diuretic class catalogued in DrugCentral. It was first approved by the FDA in 1958. DrugCentral lists 3 molecular targets, including CA1, SLC12A3 and CA2. Recorded indications include Chronic heart failure, Edema, Edema due to Hepatic Cirrhosis and Edema due to Nephrotic Syndrome.

• Approval status: ofp (first approved 1958 by the FDA).
• Drug class: Thiazide Diuretic.
• Molecular targets: CA1, SLC12A3 and CA2 (3 listed in DrugCentral).
• Indications: Chronic heart failure, Edema, Edema due to Hepatic Cirrhosis, Edema due to Nephrotic Syndrome and Hypertension with Left Ventricular Hypertrophy and others.
• ATC code: C03AA04 (Thiazides, plain).
• Molecular formula: C7H6ClN3O4S2; molecular weight 295.71 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (9)

• Chronic heart failure
• Edema
• Edema due to Hepatic Cirrhosis
• Edema due to Nephrotic Syndrome
• Hypertension with Left Ventricular Hypertrophy
• Hypertensive disorder
• Hypertensive urgency
• Peripheral Edema due to Chronic Heart Failure
• Pulmonary Edema due to Chronic Heart Failure

Off-label uses (2)

• Calcium renal calculus
• Nephrogenic diabetes insipidus

Contraindications (89)

• Acidosis
• Acute cerebrovascular insufficiency
• Acute exacerbation of asthma
• Acute hepatic failure
• Acute hepatitis
• Acute nephropathy
• Acute pancreatitis
• Acute vomiting
• Anaphylaxis
• Anemia
• Angina pectoris
• Angioedema
• Anuria
• Aortic valve stenosis
• Asthma
• Autoimmune hemolytic anemia
• Azotemia
• Benign intracranial hypertension
• Bone marrow depression
• Bronchospasm
• Calculus in biliary tract
• Cardiogenic shock
• Cerebrovascular accident
• Chronic bronchitis
• Chronic disease of respiratory system
• Chronic idiopathic constipation
• Cirrhosis of liver
• Complete atrioventricular block
• Conduction disorder of the heart
• Cough
• + 59 more

Mechanism & targets

• Established pharmacologic class: Thiazide Diuretic

Molecular targets (3)

Target	Gene	Action	Activity
Carbonic anhydrase 1	CA1	unknown	IC50 6.34
Solute carrier family 12 member 3	SLC12A3	inhibitor	A2 5.43
Carbonic anhydrase 2	CA2	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1958-09-04	FDA	—	OAK PHARMS AKORN

ATC classification

ATC code	Therapeutic hierarchy
C03AA04	CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides, plain
C03AB04	CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides and potassium in combination
C03AH01	CARDIOVASCULAR SYSTEM › DIURETICS › LOW-CEILING DIURETICS, THIAZIDES › Thiazides, combinations with psycholeptics and/or analgesics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Respiratory failure	84.7
Pulmonary hypertension	71.7
Rhinovirus infection	55.0
Respiratory distress	53.3
Pulmonary vein stenosis	44.3
Pulmonary arterial hypertension	42.3
Hypoxia	38.4
Cardiac arrest	37.6
Hypervolaemia	37.3
Hypotension	36.9
Hyperparathyroidism secondary	36.7
Hospitalisation	34.9

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Chlorothiazide is on its molecule page.

• Molecular formula: C₇H₆ClN₃O₄S₂
• Molecular weight: 295.71 g/mol
• CAS number: 58-94-6
• InChIKey: JBMKAUGHUNFTOL-UHFFFAOYSA-N
• PubChem CID: 2720

NS(=O)(=O)C1=C(Cl)C=C2N=CNS(=O)(=O)C2=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Chlorothiazide used for?

DrugCentral lists the following indications for Chlorothiazide: Chronic heart failure, Edema, Edema due to Hepatic Cirrhosis, Edema due to Nephrotic Syndrome, Hypertension with Left Ventricular Hypertrophy, Hypertensive disorder, Hypertensive urgency and Peripheral Edema due to Chronic Heart Failure and others.

How does Chlorothiazide work?

Its molecular targets in DrugCentral include CA1, SLC12A3 (inhibitor) and CA2.

When was Chlorothiazide first approved?

Chlorothiazide was first approved by the FDA in 1958.

What drug class does Chlorothiazide belong to?

Chlorothiazide is in the Thiazide Diuretic class.

What is the chemical formula of Chlorothiazide?

Chlorothiazide has the molecular formula C7H6ClN3O4S2 and a molecular weight of 295.71 g/mol.

Sources

• DrugCentral drug card 609 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200616 — compound record and bioactivity
• PubChem CID 2720 — chemical identifiers
• DrugBank DB00880 — drug record
• FDA UNII 77W477J15H — substance identity
• DailyMed: FDA labels for Chlorothiazide — current prescribing information (label search)
• UniProt P00915 (CA1) — target protein
• UniProt P55017 (SLC12A3) — target protein
• UniProt P00918 (CA2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.