Dipivefrine

Adrenergic Receptor Agonist — SENSORY ORGANS

Key facts

Dipivefrine is an ofm drug in the Adrenergic Receptor Agonist class catalogued in DrugCentral. It was first approved by the FDA in 1980. Its mechanism of action is classified as Adrenergic Agonists, Adrenergic alpha-Agonists and Adrenergic beta-Agonists. DrugCentral lists 3 molecular targets, including ADRA2A, ADRA2B and ADRA2C. Recorded indications include Open-angle glaucoma.

• Approval status: ofm (first approved 1980 by the FDA).
• Drug class: Adrenergic Receptor Agonist; alpha-Adrenergic Agonist.
• Mechanism of action: Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists.
• Molecular targets: ADRA2A, ADRA2B and ADRA2C (3 listed in DrugCentral).
• Indications: Open-angle glaucoma.
• ATC code: S01EA02 (Sympathomimetics in glaucoma therapy).
• Molecular formula: C19H29NO5; molecular weight 351.44 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Open-angle glaucoma

Contraindications (2)

• Angle-closure glaucoma
• Aphakia

Mechanism & targets

• Mechanism of action (MoA): Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists
• Established pharmacologic class: Adrenergic Receptor Agonist; alpha-Adrenergic Agonist; beta-Adrenergic Agonist; Catecholamine

Molecular targets (3)

Target	Gene	Action	Activity
Alpha-2A adrenergic receptor	ADRA2A	agonist	—
Alpha-2B adrenergic receptor	ADRA2B	agonist	—
Alpha-2C adrenergic receptor	ADRA2C	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1980-05-02	FDA	—	ALLERGAN

ATC classification

ATC code	Therapeutic hierarchy
S01EA02	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Sympathomimetics in glaucoma therapy

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dipivefrine is on its molecule page.

• Molecular formula: C₁₉H₂₉NO₅
• Molecular weight: 351.44 g/mol
• CAS number: 52365-63-6
• InChIKey: OCUJLLGVOUDECM-UHFFFAOYSA-N
• PubChem CID: 3105

CNCC(O)C1=CC(OC(=O)C(C)(C)C)=C(OC(=O)C(C)(C)C)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dipivefrine used for?

DrugCentral lists the following indications for Dipivefrine: Open-angle glaucoma.

How does Dipivefrine work?

Dipivefrine is classified as Adrenergic Agonists, Adrenergic alpha-Agonists and Adrenergic beta-Agonists; its molecular targets in DrugCentral include ADRA2A (agonist), ADRA2B (agonist) and ADRA2C (agonist).

When was Dipivefrine first approved?

Dipivefrine was first approved by the FDA in 1980.

What drug class does Dipivefrine belong to?

Dipivefrine is in the Adrenergic Receptor Agonist class.

What is the chemical formula of Dipivefrine?

Dipivefrine has the molecular formula C19H29NO5 and a molecular weight of 351.44 g/mol.

Sources

• DrugCentral drug card 922 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200833 — compound record and bioactivity
• PubChem CID 3105 — chemical identifiers
• DrugBank DB00449 — drug record
• FDA UNII 5QTH9UHV0K — substance identity
• DailyMed: FDA labels for Dipivefrine — current prescribing information (label search)
• UniProt P08913 (ADRA2A) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P18825 (ADRA2C) — target protein

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