Fosdenopterin

Cyclic Pyranopterin Monophosphate — ALIMENTARY TRACT AND METABOLISM

Key facts

Fosdenopterin is an ofp drug in the Cyclic Pyranopterin Monophosphate class catalogued in DrugCentral. It was first approved by the FDA in 2021. DrugCentral lists 1 molecular target, including MOCS1. Recorded indications include Molybdenum cofactor deficiency type A.

• Approval status: ofp (first approved 2021 by the FDA).
• Drug class: Cyclic Pyranopterin Monophosphate.
• Molecular targets: MOCS1 (1 listed in DrugCentral).
• Indications: Molybdenum cofactor deficiency type A.
• ATC code: A16AX19 (Various alimentary tract and metabolism products).
• Molecular formula: C10H14N5O8P; molecular weight 363.22 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Molybdenum cofactor deficiency type A

Mechanism & targets

• Established pharmacologic class: Cyclic Pyranopterin Monophosphate

Molecular targets (1)

Target	Gene	Action	Activity
Molybdenum cofactor biosynthesis protein 1	MOCS1	unknown	—

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2022-09-15	EMA	—	COMHARSA LIFE SCIENCES LTD	Yes
2021-02-26	FDA	—	ORIGIN	Yes

ATC classification

ATC code	Therapeutic hierarchy
A16AX19	ALIMENTARY TRACT AND METABOLISM › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS › Various alimentary tract and metabolism products

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• EMA label: MOCS1 · Testing Required
• FDA label: MOCS1 · Testing Required
• HCSC label

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Fosdenopterin is on its molecule page.

• Molecular formula: C₁₀H₁₄N₅O₈P
• Molecular weight: 363.22 g/mol
• CAS number: 150829-29-1
• InChIKey: CZAKJJUNKNPTTO-AJFJRRQVSA-N
• PubChem CID: 135463437

C1[C@@H]2[C@@H](C([C@H]3[C@@H](O2)NC4=C(N3)C(=O)NC(=N4)N)(O)O)OP(=O)(O1)O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Fosdenopterin used for?

DrugCentral lists the following indications for Fosdenopterin: Molybdenum cofactor deficiency type A.

How does Fosdenopterin work?

Its molecular targets in DrugCentral include MOCS1.

When was Fosdenopterin first approved?

Fosdenopterin was first approved by the FDA in 2021.

What drug class does Fosdenopterin belong to?

Fosdenopterin is in the Cyclic Pyranopterin Monophosphate class.

What is the chemical formula of Fosdenopterin?

Fosdenopterin has the molecular formula C10H14N5O8P and a molecular weight of 363.22 g/mol.

Sources

• DrugCentral drug card 5444 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2338675 — compound record and bioactivity
• PubChem CID 135463437 — chemical identifiers
• DrugBank DB16628 — drug record
• FDA UNII 4X7K2681Y7 — substance identity
• DailyMed: FDA labels for Fosdenopterin — current prescribing information (label search)
• UniProt Q9NZB8 (MOCS1) — target protein
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.