Methohexital

Barbiturate — NERVOUS SYSTEM

Key facts

Methohexital is an ofp drug in the Barbiturate class catalogued in DrugCentral. It was first approved by the FDA in 1960. DrugCentral lists 3 molecular targets, including GLRA1, GABRA1|GABRG2|GABRB3 and CHRNB2|CHRNA2. Recorded indications include General anesthesia and Local anesthesia.

• Approval status: ofp (first approved 1960 by the FDA).
• Drug class: Barbiturate.
• Molecular targets: GLRA1, GABRA1|GABRG2|GABRB3 and CHRNB2|CHRNA2 (3 listed in DrugCentral).
• Indications: General anesthesia and Local anesthesia.
• ATC code: N01AF01 (Barbiturates, plain).
• Molecular formula: C14H18N2O3; molecular weight 262.31 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• General anesthesia
• Local anesthesia

Contraindications (12)

• Anemia
• Asthma
• Chronic heart failure
• Chronic obstructive lung disease
• Hepatic failure
• Hypertensive urgency
• Kidney disease
• Low blood pressure
• Morbid obesity
• Porphyria
• Seizure disorder
• Shock

Mechanism & targets

• Established pharmacologic class: Barbiturate

Molecular targets (3)

Target	Gene	Action	Activity
Glycine receptor subunit alpha-1	GLRA1	unknown	—
GABA-A receptor alpha-1/beta-3/gamma-2	GABRA1|GABRG2|GABRB3	positive allosteric modulator	—
Neuronal acetylcholine receptor; alpha2/beta2	CHRNB2|CHRNA2	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1960-06-27	FDA	—	PAR STERILE PRODUCTS

ATC classification

ATC code	Therapeutic hierarchy
N01AF01	NERVOUS SYSTEM › ANESTHETICS › ANESTHETICS, GENERAL › Barbiturates, plain
N05CA15	NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Barbiturates, plain

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Methohexital is on its molecule page.

• Molecular formula: C₁₄H₁₈N₂O₃
• Molecular weight: 262.31 g/mol
• CAS number: 151-83-7
• InChIKey: NZXKDOXHBHYTKP-UHFFFAOYSA-N
• PubChem CID: 9034

CCC#CC(C)C1(CC=C)C(=O)NC(=O)N(C)C1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Methohexital used for?

DrugCentral lists the following indications for Methohexital: General anesthesia and Local anesthesia.

How does Methohexital work?

Its molecular targets in DrugCentral include GLRA1, GABRA1|GABRG2|GABRB3 (positive allosteric modulator) and CHRNB2|CHRNA2.

When was Methohexital first approved?

Methohexital was first approved by the FDA in 1960.

What drug class does Methohexital belong to?

Methohexital is in the Barbiturate class.

What is the chemical formula of Methohexital?

Methohexital has the molecular formula C14H18N2O3 and a molecular weight of 262.31 g/mol.

Sources

• DrugCentral drug card 1748 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL30219 — compound record and bioactivity
• PubChem CID 9034 — chemical identifiers
• DrugBank DB00474 — drug record
• FDA UNII E5B8ND5IPE — substance identity
• DailyMed: FDA labels for Methohexital — current prescribing information (label search)
• UniProt P23415 (GLRA1) — target protein

How this page is built: methodology · editorial policy & corrections.