Opipramol

NERVOUS SYSTEM

Key facts

Opipramol is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including SIGMAR1, EBP and ERG2. Recorded indications include Depressive disorder.

• Molecular targets: SIGMAR1, EBP, ERG2 and CACNA1B (4 listed in DrugCentral).
• Indications: Depressive disorder.
• ATC code: N06AA05 (Non-selective monoamine reuptake inhibitors).
• Molecular formula: C23H29N3O; molecular weight 363.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Depressive disorder

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	Ki 9.70
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	EBP	unknown	Ki 7.89
C-8 sterol isomerase	ERG2	unknown	Ki 7.77
Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	unknown	IC50 4.62

ATC classification

ATC code	Therapeutic hierarchy
N06AA05	NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTIDEPRESSANTS › Non-selective monoamine reuptake inhibitors

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
General physical health deterioration	184.4
Abnormal palmar/plantar creases	90.3
Product prescribing error	77.0
Product monitoring error	51.1
Dysmorphism	51.1
VACTERL syndrome	40.9
CADASIL	39.9
Hypoparathyroidism secondary	39.7
Fall	39.6
Hemivertebra	38.1
Foetal exposure during pregnancy	37.9
Transposition of the great vessels	37.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Opipramol is on its molecule page.

• Molecular formula: C₂₃H₂₉N₃O
• Molecular weight: 363.50 g/mol
• CAS number: 315-72-0
• InChIKey: YNZFUWZUGRBMHL-UHFFFAOYSA-N
• PubChem CID: 9417

OCCN1CCN(CCCN2C3=CC=CC=C3C=CC3=C2C=CC=C3)CC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Opipramol used for?

DrugCentral lists the following indications for Opipramol: Depressive disorder.

How does Opipramol work?

Its molecular targets in DrugCentral include SIGMAR1, EBP, ERG2 and CACNA1B.

What is the chemical formula of Opipramol?

Opipramol has the molecular formula C23H29N3O and a molecular weight of 363.50 g/mol.

Sources

• DrugCentral drug card 1993 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1524185 — compound record and bioactivity
• PubChem CID 9417 — chemical identifiers
• DrugBank DB12930 — drug record
• FDA UNII D23ZXO613C — substance identity
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt Q15125 (EBP) — target protein
• UniProt Q00975 (CACNA1B) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.