Phenmetrazine
Drug profile
Also known as: 3-Methyl-2-phenylmorpholine, 3-Methyl-2-phenyltetrahydro-2H-1,4-oxazine, fenmetrazina, fenmetrazine, oxazimedrine, phenmetrazin, phenmetrazine HCl, phenmetrazine hydrochloride, phenmetrazine teoclate
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Phenmetrazine is an ofm drug catalogued in DrugCentral. DrugCentral lists 3 molecular targets, including SLC6A2, SLC6A3 and MAOA. Recorded indications include Obesity.
- Approval status: ofm.
- Molecular targets: SLC6A2, SLC6A3 and MAOA (3 listed in DrugCentral).
- Indications: Obesity.
- Molecular formula: C11H15NO; molecular weight 177.25 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Obesity
Contraindications (18)
- Alcoholism
- Arteriosclerotic vascular disease
- Breastfeeding (mother)
- Chronic heart failure
- Conduction disorder of the heart
- Diabetes mellitus type 1
- Diabetes mellitus type 2
- Disorder of coronary artery
- Drug-induced psychosis
- Epilepsy
- Feeling agitated
- Glaucoma
- Heart valve disorder
- Hypertensive disorder
- Hypertensive urgency
- Hyperthyroidism
- Pulmonary hypertension
- Substance abuse
Mechanism & targets
Molecular targets (3)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Sodium-dependent noradrenaline transporter | SLC6A2 | inhibitor | EC50 7.30 |
| Sodium-dependent dopamine transporter | SLC6A3 | inhibitor | EC50 6.88 |
| Amine oxidase [flavin-containing] A | MAOA | unknown | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| — | FDA | — | BOEHRINGER INGELHEIM |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Phenmetrazine is on its molecule page.
| Molecular formula | C11H15NO |
|---|---|
| Molecular weight | 177.25 g/mol |
| CAS number | 134-49-6 |
| InChIKey | OOBHFESNSZDWIU-UHFFFAOYSA-N |
| PubChem CID | 4762 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Phenmetrazine used for?
DrugCentral lists the following indications for Phenmetrazine: Obesity.
How does Phenmetrazine work?
Its molecular targets in DrugCentral include SLC6A2 (inhibitor), SLC6A3 (inhibitor) and MAOA.
What is the chemical formula of Phenmetrazine?
Phenmetrazine has the molecular formula C11H15NO and a molecular weight of 177.25 g/mol.
Browse: all drugs starting with P · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 2133 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1200483 — compound record and bioactivity
- PubChem CID 4762 — chemical identifiers
- DrugBank DB00830 — drug record
- FDA UNII XA501VL3VR — substance identity
- DailyMed: FDA labels for Phenmetrazine — current prescribing information (label search)
- UniProt P23975 (SLC6A2) — target protein
- UniProt Q01959 (SLC6A3) — target protein
- UniProt P21397 (MAOA) — target protein
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