Secobarbital

NERVOUS SYSTEM

Key facts

Secobarbital is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1950. DrugCentral lists 2 molecular targets, including MMP9 and GABRA1|GABRG2|GABRB2. Recorded indications include Epilepsy, General anesthesia, Insomnia and Local anesthesia.

• Approval status: ofm (first approved 1950 by the FDA).
• Molecular targets: MMP9 and GABRA1|GABRG2|GABRB2 (2 listed in DrugCentral).
• Indications: Epilepsy, General anesthesia, Insomnia, Local anesthesia and Seizure disorder and others.
• ATC code: N05CA06 (Barbiturates, plain).
• Molecular formula: C12H18N2O3; molecular weight 238.29 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (8)

• Epilepsy
• General anesthesia
• Insomnia
• Local anesthesia
• Seizure disorder
• Severe anxiety (panic)
• Status epilepticus
• Tetanus Adjunct Treatment

Contraindications (28)

• Acute exacerbation of asthma
• Alcoholism
• Anemia
• Apnea
• Chronic obstructive lung disease
• Decreased respiratory function
• Depressive disorder
• Disease of liver
• Disorder of lung
• Heart disease
• Hepatic coma
• Hepatic encephalopathy
• Hepatic failure
• Hyperactive behavior
• Hyperammonemia
• Hypertensive disorder
• Kidney disease
• Low blood pressure
• Neutropenic disorder
• Pneumonia
• Porphyria
• Pregnancy, function
• Respiratory insufficiency
• Sleep apnea
• Sleep automatism
• Substance abuse
• Suicidal thoughts
• Thrombocytopenic disorder

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Matrix metalloproteinase-9	MMP9	unknown	IC50 5.58
GABA-A receptor alpha-1/beta-2/gamma-2	GABRA1|GABRG2|GABRB2	positive allosteric modulator	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1950-07-19	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
N05CA06	NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Barbiturates, plain

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Secobarbital is on its molecule page.

• Molecular formula: C₁₂H₁₈N₂O₃
• Molecular weight: 238.29 g/mol
• CAS number: 76-73-3
• InChIKey: KQPKPCNLIDLUMF-UHFFFAOYSA-N
• PubChem CID: 5193

CCCC(C)C1(CC=C)C(=O)NC(=O)NC1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Secobarbital used for?

DrugCentral lists the following indications for Secobarbital: Epilepsy, General anesthesia, Insomnia, Local anesthesia, Seizure disorder, Severe anxiety (panic), Status epilepticus and Tetanus Adjunct Treatment.

How does Secobarbital work?

Its molecular targets in DrugCentral include MMP9 and GABRA1|GABRG2|GABRB2 (positive allosteric modulator).

When was Secobarbital first approved?

Secobarbital was first approved by the FDA in 1950.

What is the chemical formula of Secobarbital?

Secobarbital has the molecular formula C12H18N2O3 and a molecular weight of 238.29 g/mol.

Sources

• DrugCentral drug card 2428 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200903 — compound record and bioactivity
• PubChem CID 5193 — chemical identifiers
• DrugBank DB00418 — drug record
• FDA UNII 1P7H87IN75 — substance identity
• DailyMed: FDA labels for Secobarbital — current prescribing information (label search)
• UniProt P14780 (MMP9) — target protein

How this page is built: methodology · editorial policy & corrections.