Terbutaline

RESPIRATORY SYSTEM

Key facts

Terbutaline is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1974. DrugCentral lists 3 molecular targets, including ADRB1, ADRB2 and ADRB2. Recorded indications include Acute exacerbation of asthma, Asthma, Asthma management and Bronchitis.

• Approval status: ofp (first approved 1974 by the FDA).
• Molecular targets: ADRB1, ADRB2 and ADRB2 (3 listed in DrugCentral).
• Indications: Acute exacerbation of asthma, Asthma, Asthma management, Bronchitis and Bronchospasm Prevention and others.
• ATC code: R03AC03 (Selective beta-2-adrenoreceptor agonists).
• Molecular formula: C12H19NO3; molecular weight 225.29 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (11)

• Acute exacerbation of asthma
• Asthma
• Asthma management
• Bronchitis
• Bronchospasm Prevention
• Chronic Obstructive Pulmonary Disease with Bronchospasms
• Itching of skin
• Minor Skin Wound Pain
• Pulmonary emphysema
• Skin irritation
• Tear film insufficiency

Off-label uses (3)

• Bronchiectasis
• Keratoconjunctivitis sicca
• Premature labor

Contraindications (17)

• Chronic myocardial ischemia
• Compression of umbilical cord
• Conduction disorder of the heart
• Decreased respiratory function
• Denuded skin
• Diabetes mellitus
• Epilepsy
• Hyperglycemia
• Hypertensive disorder
• Hyperthyroidism
• Hypokalemia
• Ketoacidosis
• Myocardial ischemia
• Open wound
• Placental abruption
• Pulmonary edema
• Seizure disorder

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Beta-1 adrenergic receptor	ADRB1	agonist	EC50 5.80
Beta-2 adrenergic receptor	ADRB2	agonist	Ki 5.60
Beta-2 adrenergic receptor	ADRB2	unknown	Kd 5.40

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1974-03-25	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
R03AC03	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › ADRENERGICS, INHALANTS › Selective beta-2-adrenoreceptor agonists
R03CC03	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › ADRENERGICS FOR SYSTEMIC USE › Selective beta-2-adrenoreceptor agonists
R03CC53	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › ADRENERGICS FOR SYSTEMIC USE › Selective beta-2-adrenoreceptor agonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Asthma	480.1
Dyspnoea	251.9
Wheezing	211.8
Forced expiratory volume decreased	122.7
Middle insomnia	121.3
Cough	120.4
Obstructive airways disorder	110.3
Full blood count abnormal	104.1
Sleep disorder due to a general medical condition	102.2
Chest discomfort	100.9
Cholestasis	90.6
Sputum discoloured	88.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Terbutaline is on its molecule page.

• Molecular formula: C₁₂H₁₉NO₃
• Molecular weight: 225.29 g/mol
• CAS number: 23031-25-6
• InChIKey: XWTYSIMOBUGWOL-UHFFFAOYSA-N
• PubChem CID: 5403

CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Terbutaline used for?

DrugCentral lists the following indications for Terbutaline: Acute exacerbation of asthma, Asthma, Asthma management, Bronchitis, Bronchospasm Prevention, Chronic Obstructive Pulmonary Disease with Bronchospasms, Itching of skin and Minor Skin Wound Pain and others.

How does Terbutaline work?

Its molecular targets in DrugCentral include ADRB1 (agonist), ADRB2 (agonist) and ADRB2.

When was Terbutaline first approved?

Terbutaline was first approved by the FDA in 1974.

What is the chemical formula of Terbutaline?

Terbutaline has the molecular formula C12H19NO3 and a molecular weight of 225.29 g/mol.

Sources

• DrugCentral drug card 2598 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1315867 — compound record and bioactivity
• PubChem CID 5403 — chemical identifiers
• DrugBank DB00871 — drug record
• FDA UNII N8ONU3L3PG — substance identity
• DailyMed: FDA labels for Terbutaline — current prescribing information (label search)
• UniProt P08588 (ADRB1) — target protein
• UniProt P07550 (ADRB2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.