Trioxsalen

Psoralen — DERMATOLOGICALS

Key facts

Trioxsalen is an ofm drug in the Psoralen class catalogued in DrugCentral. It was first approved by the FDA in 1964. DrugCentral lists 3 molecular targets, including ADORA2A, MAOA and HTR2C. Recorded indications include Photosensitivity, Skin Pigmentation Enhancement and Vitiligo.

• Approval status: ofm (first approved 1964 by the FDA).
• Drug class: Psoralen.
• Molecular targets: ADORA2A, MAOA and HTR2C (3 listed in DrugCentral).
• Indications: Photosensitivity, Skin Pigmentation Enhancement and Vitiligo.
• ATC code: D05AD01 (Psoralens for topical use).
• Molecular formula: C14H12O3; molecular weight 228.25 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Photosensitivity
• Skin Pigmentation Enhancement
• Vitiligo

Mechanism & targets

• Established pharmacologic class: Psoralen

Molecular targets (3)

Target	Gene	Action	Activity
Adenosine receptor A2a	ADORA2A	unknown	Ki 6.13
Amine oxidase [flavin-containing] A	MAOA	unknown	IC50 6.08
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 5.91

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1964-07-24	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
D05AD01	DERMATOLOGICALS › ANTIPSORIATICS › ANTIPSORIATICS FOR TOPICAL USE › Psoralens for topical use
D05BA01	DERMATOLOGICALS › ANTIPSORIATICS › ANTIPSORIATICS FOR SYSTEMIC USE › Psoralens for systemic use

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Trioxsalen is on its molecule page.

• Molecular formula: C₁₄H₁₂O₃
• Molecular weight: 228.25 g/mol
• CAS number: 3902-71-4
• InChIKey: FMHHVULEAZTJMA-UHFFFAOYSA-N
• PubChem CID: 5585

CC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Trioxsalen used for?

DrugCentral lists the following indications for Trioxsalen: Photosensitivity, Skin Pigmentation Enhancement and Vitiligo.

How does Trioxsalen work?

Its molecular targets in DrugCentral include ADORA2A, MAOA and HTR2C.

When was Trioxsalen first approved?

Trioxsalen was first approved by the FDA in 1964.

What drug class does Trioxsalen belong to?

Trioxsalen is in the Psoralen class.

What is the chemical formula of Trioxsalen?

Trioxsalen has the molecular formula C14H12O3 and a molecular weight of 228.25 g/mol.

Sources

• DrugCentral drug card 2759 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1475 — compound record and bioactivity
• PubChem CID 5585 — chemical identifiers
• DrugBank DB04571 — drug record
• FDA UNII Y6UY8OV51T — substance identity
• DailyMed: FDA labels for Trioxsalen — current prescribing information (label search)
• UniProt P29274 (ADORA2A) — target protein
• UniProt P21397 (MAOA) — target protein
• UniProt P28335 (HTR2C) — target protein

How this page is built: methodology · editorial policy & corrections.