Vilanterol

beta2-Adrenergic Agonist — RESPIRATORY SYSTEM

Key facts

Vilanterol is an onp drug in the beta2-Adrenergic Agonist class catalogued in DrugCentral. It was first approved by the FDA in 2013. Its mechanism of action is classified as Adrenergic beta2-Agonists. DrugCentral lists 3 molecular targets, including ADRB2, ADRB1 and ADRB3. Recorded indications include Asthma, Chronic bronchitis, Chronic obstructive lung disease and Pulmonary emphysema.

• Approval status: onp (first approved 2013 by the FDA).
• Drug class: beta2-Adrenergic Agonist.
• Mechanism of action: Adrenergic beta2-Agonists.
• Molecular targets: ADRB2, ADRB1 and ADRB3 (3 listed in DrugCentral).
• Indications: Asthma, Chronic bronchitis, Chronic obstructive lung disease and Pulmonary emphysema.
• ATC code: R03AK10 (Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics).
• Molecular formula: C24H33Cl2NO5; molecular weight 486.43 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Asthma
• Chronic bronchitis
• Chronic obstructive lung disease
• Pulmonary emphysema

Mechanism & targets

• Mechanism of action (MoA): Adrenergic beta2-Agonists
• Established pharmacologic class: beta2-Adrenergic Agonist

Molecular targets (3)

Target	Gene	Action	Activity
Beta-2 adrenergic receptor	ADRB2	agonist	EC50 9.40
Beta-1 adrenergic receptor	ADRB1	unknown	EC50 6.40
Beta-3 adrenergic receptor	ADRB3	unknown	EC50 6.10

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2013-11-13	EMA	—	GlaxoSmithKline (Ireland) Limited
2013-05-10	FDA	—	GLAXO GRP LTD

ATC classification

ATC code	Therapeutic hierarchy
R03AK10	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › ADRENERGICS, INHALANTS › Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
R03AL03	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › ADRENERGICS, INHALANTS › Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
R03AL08	RESPIRATORY SYSTEM › DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES › ADRENERGICS, INHALANTS › Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Appendicolith	745.9
Appendicitis	616.5
Blood phosphorus increased	491.8
Cardiogenic shock	487.1
Ventricular fibrillation	452.7
Ascites	393.0
Blood uric acid increased	328.9
Stress	324.2
Multiple organ dysfunction syndrome	290.2
Abdominal distension	288.6
Myasthenia gravis	285.0
Hyperphosphataemia	281.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Vilanterol is on its molecule page.

• Molecular formula: C₂₄H₃₃Cl₂NO₅
• Molecular weight: 486.43 g/mol
• CAS number: 503068-34-6
• InChIKey: DAFYYTQWSAWIGS-DEOSSOPVSA-N
• PubChem CID: 10184665

OCC1=C(O)C=CC(=C1)[C@@H](O)CNCCCCCCOCCOCC1=C(Cl)C=CC=C1Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Vilanterol used for?

DrugCentral lists the following indications for Vilanterol: Asthma, Chronic bronchitis, Chronic obstructive lung disease and Pulmonary emphysema.

How does Vilanterol work?

Vilanterol is classified as Adrenergic beta2-Agonists; its molecular targets in DrugCentral include ADRB2 (agonist), ADRB1 and ADRB3.

When was Vilanterol first approved?

Vilanterol was first approved by the FDA in 2013.

What drug class does Vilanterol belong to?

Vilanterol is in the beta2-Adrenergic Agonist class.

What is the chemical formula of Vilanterol?

Vilanterol has the molecular formula C24H33Cl2NO5 and a molecular weight of 486.43 g/mol.

Sources

• DrugCentral drug card 4799 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1084172 — compound record and bioactivity
• PubChem CID 10184665 — chemical identifiers
• DrugBank DB09082 — drug record
• FDA UNII 028LZY775B — substance identity
• DailyMed: FDA labels for Vilanterol — current prescribing information (label search)
• UniProt P07550 (ADRB2) — target protein
• UniProt P08588 (ADRB1) — target protein
• UniProt P13945 (ADRB3) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.