3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione

C237H458N16O32 — CID 160824313

About 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione

3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione (PubChem CID 160824313) has the molecular formula C237H458N16O32 and a molecular weight of 4044.35 g/mol. Its IUPAC name is 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione.

Molecular Properties

• Compound Name: 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione
• PubChem CID: 160824313
• Molecular Formula: C237H458N16O32
• Molecular Weight: 4044.35 g/mol
• Exact Mass: 4041.47
• IUPAC Name: 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione
• SMILES: CCN1CC(=O)N(C(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCO)C1=O.CCN1CC(=O)N(CCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCO)C1=O.CCN1CC(=O)N(CCCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CCCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCO)C1=O.CCN1CC(=O)N(CCCCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O
• InChI: InChI=1S/C32H62N2O4.C31H60N2O4.2C30H58N2O4.2C29H56N2O4.2C28H54N2O4/c1-6-31(7-2,20-12-11-17-25-35)22-14-18-26-38-27-19-15-23-32(8-3,9-4)21-13-16-24-34-29(36)28-33(10-5)30(34)37;1-6-30(7-2,19-12-11-15-24-34)20-13-16-25-37-26-17-14-21-31(8-3,9-4)22-18-23-33-28(35)27-32(10-5)29(33)36;1-6-29(7-2,18-11-14-23-33)19-12-15-24-36-25-16-13-20-30(8-3,9-4)21-17-22-32-27(34)26-31(10-5)28(32)35;1-6-29(7-2,18-12-11-15-23-33)19-13-16-24-36-25-17-14-20-30(8-3,9-4)21-22-32-27(34)26-31(10-5)28(32)35;1-6-28(7-2,17-11-14-22-32)18-12-15-23-35-24-16-13-19-29(8-3,9-4)20-21-31-26(33)25-30(10-5)27(31)34;1-6-28(7-2,18-12-11-15-21-32)19-13-16-22-35-23-17-14-20-29(8-3,9-4)25-31-26(33)24-30(10-5)27(31)34;1-6-27(7-2,17-11-14-20-31)18-12-15-21-34-22-16-13-19-28(8-3,9-4)24-30-25(32)23-29(10-5)26(30)33;1-6-27(7-2,18-12-11-15-21-31)19-13-16-22-34-23-17-14-20-28(8-3,9-4)30-25(32)24-29(10-5)26(30)33/h35H,6-28H2,1-5H3;34H,6-27H2,1-5H3;2*33H,6-26H2,1-5H3;2*32H,6-25H2,1-5H3;2*31H,6-24H2,1-5H3
• InChIKey: SFYPFJVFWDCNQG-UHFFFAOYSA-N
• XLogP: 56.44
• TPSA: 560.64 Ų
• H-Bond Donors: 8
• H-Bond Acceptors: 32
• Rotatable Bonds: 181
• Heavy Atoms: 285
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	4044.35
LogP ≤ 5	56.44
H-Bond Donors ≤ 5	8
H-Bond Acceptors ≤ 10	32

Computed Properties (RDKit)

• Structural Alerts: {'alert_name': 'Aliphatic_long_chain', 'substructure': 'N/A'}, {'alert_name': 'hydantoin', 'substructure': 'N/A'}

Frequently Asked Questions

What is the IUPAC name of 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione?

The IUPAC name of 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione (CID 160824313) is 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione.

What is the SMILES notation for 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione?

The canonical SMILES for 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione is CCN1CC(=O)N(C(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCO)C1=O.CCN1CC(=O)N(CCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCO)C1=O.CCN1CC(=O)N(CCCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.CCN1CC(=O)N(CCCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCO)C1=O.CCN1CC(=O)N(CCCCC(CC)(CC)CCCCOCCCCC(CC)(CC)CCCCCO)C1=O.

What is the InChIKey of 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione?

The InChIKey is SFYPFJVFWDCNQG-UHFFFAOYSA-N. The full InChI is InChI=1S/C32H62N2O4.C31H60N2O4.2C30H58N2O4.2C29H56N2O4.2C28H54N2O4/c1-6-31(7-2,20-12-11-17-25-35)22-14-18-26-38-27-19-15-23-32(8-3,9-4)21-13-16-24-34-29(36)28-33(10-5)30(34)37;1-6-30(7-2,19-12-11-15-24-34)20-13-16-25-37-26-17-14-21-31(8-3,9-4)22-18-23-33-28(35)27-32(10-5)29(33)36;1-6-29(7-2,18-11-14-23-33)19-12-15-24-36-25-16-13-20-30(8-3,9-4)21-17-22-32-27(34)26-31(10-5)28(32)35;1-6-29(7-2,18-12-11-15-23-33)19-13-16-24-36-25-17-14-20-30(8-3,9-4)21-22-32-27(34)26-31(10-5)28(32)35;1-6-28(7-2,17-11-14-22-32)18-12-15-23-35-24-16-13-19-29(8-3,9-4)20-21-31-26(33)25-30(10-5)27(31)34;1-6-28(7-2,18-12-11-15-21-32)19-13-16-22-35-23-17-14-20-29(8-3,9-4)25-31-26(33)24-30(10-5)27(31)34;1-6-27(7-2,17-11-14-20-31)18-12-15-21-34-22-16-13-19-28(8-3,9-4)24-30-25(32)23-29(10-5)26(30)33;1-6-27(7-2,18-12-11-15-21-31)19-13-16-22-34-23-17-14-20-28(8-3,9-4)30-25(32)24-29(10-5)26(30)33/h35H,6-28H2,1-5H3;34H,6-27H2,1-5H3;2*33H,6-26H2,1-5H3;2*32H,6-25H2,1-5H3;2*31H,6-24H2,1-5H3.

What are the key properties of 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione?

3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione has a molecular weight of 4044.35 g/mol, XLogP of 56.44, 181 rotatable bonds, 8 hydrogen bond donors, and 32 hydrogen bond acceptors.

Where does this data come from?

All data for 3-[7-(5,5-diethyl-10-hydroxydecoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-10-hydroxydecoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[9-(5,5-diethyl-10-hydroxydecoxy)-5,5-diethylnonyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-10-hydroxydecoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-10-hydroxydecoxy)-3-ethylheptan-3-yl]-1-ethylimidazolidine-2,4-dione;3-[7-(5,5-diethyl-9-hydroxynonoxy)-3,3-diethylheptyl]-1-ethylimidazolidine-2,4-dione;3-[6-(5,5-diethyl-9-hydroxynonoxy)-2,2-diethylhexyl]-1-ethylimidazolidine-2,4-dione;3-[8-(5,5-diethyl-9-hydroxynonoxy)-4,4-diethyloctyl]-1-ethylimidazolidine-2,4-dione is sourced from PubChem (CID 160824313), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).