Biotin

ALIMENTARY TRACT AND METABOLISM

Key facts

Biotin is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1953. DrugCentral lists 1 molecular target, including IDE. Recorded indications include Biotin deficiency disease.

• Approval status: ofp (first approved 1953 by the FDA).
• Molecular targets: IDE (1 listed in DrugCentral).
• Indications: Biotin deficiency disease.
• ATC code: A11HA05 (Other plain vitamin preparations).
• Molecular formula: C10H16N2O3S; molecular weight 244.32 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Biotin deficiency disease

Off-label uses (3)

• Biotinidase deficiency
• Holocarboxylase synthase deficiency
• Propionic acidemia

Contraindications (8)

• Constipation
• Dehydration
• Hypercalcemia
• Hyperparathyroidism
• Kidney disease
• Kidney stone
• Osteolysis
• Sarcoidosis

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Insulin-degrading enzyme	IDE	unknown	EC50 5.60

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1953-02-20	FDA	—	HOSPIRA

ATC classification

ATC code	Therapeutic hierarchy
A11HA05	ALIMENTARY TRACT AND METABOLISM › VITAMINS › OTHER PLAIN VITAMIN PREPARATIONS › Other plain vitamin preparations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Synovitis	329.0
Hypertrichosis	292.9
Hand deformity	292.8
Product dose omission issue	274.2
Systemic lupus erythematosus	257.0
Glossodynia	243.8
Contraindicated product administered	225.7
Duodenal ulcer perforation	214.7
Maternal exposure during pregnancy	210.3
Pericarditis	207.8
Fractional exhaled nitric oxide increased	203.9
Helicobacter infection	203.8

Chemical structure

• Molecular formula: C₁₀H₁₆N₂O₃S
• Molecular weight: 244.32 g/mol
• CAS number: —
• InChIKey: YBJHBAHKTGYVGT-ZKWXMUAHSA-N
• PubChem CID: 171548

OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Biotin used for?

DrugCentral lists the following indications for Biotin: Biotin deficiency disease.

How does Biotin work?

Its molecular targets in DrugCentral include IDE.

When was Biotin first approved?

Biotin was first approved by the FDA in 1953.

What is the chemical formula of Biotin?

Biotin has the molecular formula C10H16N2O3S and a molecular weight of 244.32 g/mol.

Sources

• DrugCentral drug card 373 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL857 — compound record and bioactivity
• PubChem CID 171548 — chemical identifiers
• DrugBank DB00121 — drug record
• FDA UNII 6SO6U10H04 — substance identity
• DailyMed: FDA labels for Biotin — current prescribing information (label search)
• UniProt P14735 (IDE) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.