Riboflavin

ALIMENTARY TRACT AND METABOLISM

Key facts

Riboflavin is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1953. DrugCentral lists 3 molecular targets, including Riboflavin-binding protein, BLVRB and RFK. Recorded indications include Mineral deficiency, Mineral Deficiency Prevention, Vitamin deficiency and Vitamin Deficiency Prevention.

• Approval status: ofp (first approved 1953 by the FDA).
• Molecular targets: Riboflavin-binding protein, BLVRB and RFK (3 listed in DrugCentral).
• Indications: Mineral deficiency, Mineral Deficiency Prevention, Vitamin deficiency and Vitamin Deficiency Prevention.
• ATC code: A11HA04 (Other plain vitamin preparations).
• Molecular formula: C17H20N4O6; molecular weight 376.37 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Mineral deficiency
• Mineral Deficiency Prevention
• Vitamin deficiency
• Vitamin Deficiency Prevention

Off-label uses (3)

• Glutaric aciduria, type 1
• Glutaric aciduria, type 2
• Migraine Prevention

Contraindications (34)

• Acute Thromboembolic Stroke
• Agoraphobia
• Alcoholism
• Atrophic gastritis
• Blood coagulation disorder
• Cardiovascular event risk
• Chronic heart failure
• Conduction disorder of the heart
• Coronary artery bypass graft
• Disease of liver
• Gastrectomy
• Gastrointestinal hemorrhage
• Gastrointestinal perforation
• Gastrointestinal ulcer
• Hemophilia
• Hepatic failure
• Hypertensive disorder
• Hypokalemia
• Impaired renal function disorder
• Insomnia
• Kidney disease
• Leber's optic atrophy
• Low blood pressure
• Myocardial infarction
• Myocardial infarction in recovery phase
• Myocardial ischemia
• Necrotizing enterocolitis in fetus OR newborn
• Obsessive-compulsive disorder
• Obstruction of bile duct
• Panic disorder
• + 4 more

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Riboflavin-binding protein	—	unknown	Kd 8.30
Flavin reductase (NADPH)	BLVRB	unknown	—
Riboflavin kinase	RFK	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1953-02-20	FDA	—	HOSPIRA

ATC classification

ATC code	Therapeutic hierarchy
A11HA04	ALIMENTARY TRACT AND METABOLISM › VITAMINS › OTHER PLAIN VITAMIN PREPARATIONS › Other plain vitamin preparations
S01XA26	SENSORY ORGANS › OPHTHALMOLOGICALS › OTHER OPHTHALMOLOGICALS › Other ophthalmologicals

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Systemic lupus erythematosus	2744.1
Pemphigus	2713.3
Glossodynia	2368.1
Hand deformity	2031.9
Arthropathy	1949.2
Alopecia	1796.9
Abdominal discomfort	1762.8
Toxicity to various agents	1715.1
Wound	1667.3
Synovitis	1572.1
Maternal exposure during pregnancy	1544.4
Completed suicide	1391.3

Chemical structure

• Molecular formula: C₁₇H₂₀N₄O₆
• Molecular weight: 376.37 g/mol
• CAS number: 83-88-5
• InChIKey: AUNGANRZJHBGPY-SCRDCRAPSA-N
• PubChem CID: 493570

CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO)C1=NC(=O)NC(=O)C1=N2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Riboflavin used for?

DrugCentral lists the following indications for Riboflavin: Mineral deficiency, Mineral Deficiency Prevention, Vitamin deficiency and Vitamin Deficiency Prevention.

How does Riboflavin work?

Its molecular targets in DrugCentral include Riboflavin-binding protein, BLVRB and RFK.

When was Riboflavin first approved?

Riboflavin was first approved by the FDA in 1953.

What is the chemical formula of Riboflavin?

Riboflavin has the molecular formula C17H20N4O6 and a molecular weight of 376.37 g/mol.

Sources

• DrugCentral drug card 2834 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1534 — compound record and bioactivity
• PubChem CID 493570 — chemical identifiers
• DrugBank DB00140 — drug record
• FDA UNII TLM2976OFR — substance identity
• DailyMed: FDA labels for Riboflavin — current prescribing information (label search)
• UniProt P30043 (BLVRB) — target protein
• UniProt Q969G6 (RFK) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.