Brompheniramine
RESPIRATORY SYSTEM
Also known as: bromopheniramine, bromphen, brompheniramine maleate, parabromdylamine, parabromodylamine
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Brompheniramine is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1957. DrugCentral lists 3 molecular targets, including HRH1, KCNH2 and SCN1A|SCN2A|SCN3A. Recorded indications include Allergic conjunctivitis, Allergic rhinitis, Dermatographic urticaria and Influenza-like symptoms.
- Approval status: ofp (first approved 1957 by the FDA).
- Molecular targets: HRH1, KCNH2 and SCN1A|SCN2A|SCN3A (3 listed in DrugCentral).
- Indications: Allergic conjunctivitis, Allergic rhinitis, Dermatographic urticaria, Influenza-like symptoms and Itching of skin and others.
- ATC code: R06AB01 (Substituted alkylamines).
- Molecular formula: C16H19BrN2; molecular weight 319.25 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (9)
- Allergic conjunctivitis
- Allergic rhinitis
- Dermatographic urticaria
- Influenza-like symptoms
- Itching of skin
- Nasal discharge
- Seasonal allergic rhinitis
- Urticaria
- Vasomotor rhinitis
Contraindications (91)
- Achalasia of esophagus
- Acidosis
- Acute abdominal pain
- Acute exacerbation of asthma
- Acute hepatitis
- Acute pancreatitis
- Alcohol intoxication
- Alcohol withdrawal delirium
- Alcoholism
- Angle-closure glaucoma
- Arterial thrombosis
- Arteriosclerotic vascular disease
- Asthenia
- Atony of colon
- Autonomic dysreflexia
- Benign intracranial hypertension
- Benign prostatic hyperplasia
- Bladder outflow obstruction
- Bleeding
- Bradycardia
- Brain damage
- Breastfeeding (mother)
- Central nervous system depression
- Chronic disease of respiratory system
- Chronic heart failure
- Chronic idiopathic constipation
- Chronic lung disease
- Chronic obstructive lung disease
- Coma
- Complete trisomy 21 syndrome
- + 61 more
Mechanism & targets
Molecular targets (3)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Histamine H1 receptor | HRH1 | antagonist | Ki 8.22 |
| Potassium voltage-gated channel subfamily H member 2 | KCNH2 | unknown | IC50 6.05 |
| Sodium channel alpha subunits; brain (Types I, II, III) | SCN1A|SCN2A|SCN3A | unknown | IC50 4.96 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1957-08-23 | FDA | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
R06AB01 | RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted alkylamines |
R06AB51 | RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted alkylamines |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Brompheniramine is on its molecule page.
| Molecular formula | C16H19BrN2 |
|---|---|
| Molecular weight | 319.25 g/mol |
| CAS number | 86-22-6 |
| InChIKey | ZDIGNSYAACHWNL-UHFFFAOYSA-N |
| PubChem CID | 6834 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Brompheniramine used for?
DrugCentral lists the following indications for Brompheniramine: Allergic conjunctivitis, Allergic rhinitis, Dermatographic urticaria, Influenza-like symptoms, Itching of skin, Nasal discharge, Seasonal allergic rhinitis and Urticaria and others.
How does Brompheniramine work?
Its molecular targets in DrugCentral include HRH1 (antagonist), KCNH2 and SCN1A|SCN2A|SCN3A.
When was Brompheniramine first approved?
Brompheniramine was first approved by the FDA in 1957.
What is the chemical formula of Brompheniramine?
Brompheniramine has the molecular formula C16H19BrN2 and a molecular weight of 319.25 g/mol.
Browse: all drugs starting with B · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 408 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1200961 — compound record and bioactivity
- PubChem CID 6834 — chemical identifiers
- DrugBank DB00835 — drug record
- FDA UNII H57G17P2FN — substance identity
- DailyMed: FDA labels for Brompheniramine — current prescribing information (label search)
- UniProt P35367 (HRH1) — target protein
- UniProt Q12809 (KCNH2) — target protein
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.