Pheniramine

DERMATOLOGICALS

Key facts

Pheniramine is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1994. DrugCentral lists 3 molecular targets, including HRH4, SCN1A|SCN2A|SCN3A and HRH1. Recorded indications include Allergic conjunctivitis, Allergic rhinitis, Anaphylaxis Adjunct and Common cold.

• Approval status: ofp (first approved 1994 by the FDA).
• Molecular targets: HRH4, SCN1A|SCN2A|SCN3A and HRH1 (3 listed in DrugCentral).
• Indications: Allergic conjunctivitis, Allergic rhinitis, Anaphylaxis Adjunct, Common cold and Cough and others.
• ATC code: D04AA16 (Antihistamines for topical use).
• Molecular formula: C16H20N2; molecular weight 240.35 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (20)

• Allergic conjunctivitis
• Allergic rhinitis
• Anaphylaxis Adjunct
• Common cold
• Cough
• Dermatographic urticaria
• Fever
• Headache disorder
• Influenza-like symptoms
• Itching of skin
• Nasal congestion
• Nasal discharge
• Ocular Itching
• Red eye
• Seasonal allergic rhinitis
• Sinus headache
• Sneezing
• Sore throat symptom
• Urticaria
• Vasomotor rhinitis

Contraindications (80)

• Achalasia of esophagus
• Acidosis
• Acute abdominal pain
• Acute coronary syndrome
• Acute erosive gastritis
• Acute exacerbation of asthma
• Acute hepatitis
• Acute nephropathy
• Acute pancreatitis
• Acute Thromboembolic Stroke
• Acute tuberculosis
• Agoraphobia
• Alcohol intoxication
• Alcohol withdrawal delirium
• Alcoholism
• Anemia
• Anemia due to enzyme deficiency
• Angle-closure glaucoma
• Arterial hemorrhage
• Arterial thrombosis
• Arteriosclerotic vascular disease
• Asthenia
• Atony of colon
• Autonomic dysreflexia
• Benign intracranial hypertension
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bleeding
• Blood coagulation disorder
• Body fluid retention
• + 50 more

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Histamine H4 receptor	HRH4	unknown	Ki 5.38
Sodium channel alpha subunits; brain (Types I, II, III)	SCN1A|SCN2A|SCN3A	unknown	IC50 4.48
Histamine H1 receptor	HRH1	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1994-06-08	FDA	—	ALCON

ATC classification

ATC code	Therapeutic hierarchy
D04AA16	DERMATOLOGICALS › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › Antihistamines for topical use
R06AB05	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted alkylamines

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Febrile neutropenia	66.9
Kounis syndrome	34.9

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Pheniramine is on its molecule page.

• Molecular formula: C₁₆H₂₀N₂
• Molecular weight: 240.35 g/mol
• CAS number: —
• InChIKey: IJHNSHDBIRRJRN-UHFFFAOYSA-N
• PubChem CID: 4761

CN(C)CCC(C1=CC=CC=C1)C1=NC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pheniramine used for?

DrugCentral lists the following indications for Pheniramine: Allergic conjunctivitis, Allergic rhinitis, Anaphylaxis Adjunct, Common cold, Cough, Dermatographic urticaria, Fever and Headache disorder and others.

How does Pheniramine work?

Its molecular targets in DrugCentral include HRH4, SCN1A|SCN2A|SCN3A and HRH1 (antagonist).

When was Pheniramine first approved?

Pheniramine was first approved by the FDA in 1994.

What is the chemical formula of Pheniramine?

Pheniramine has the molecular formula C16H20N2 and a molecular weight of 240.35 g/mol.

Sources

• DrugCentral drug card 2132 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1193 — compound record and bioactivity
• PubChem CID 4761 — chemical identifiers
• DrugBank DB01620 — drug record
• FDA UNII 134FM9ZZ6M — substance identity
• DailyMed: FDA labels for Pheniramine — current prescribing information (label search)
• UniProt Q9H3N8 (HRH4) — target protein
• UniProt P35367 (HRH1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.