Dexbrompheniramine

RESPIRATORY SYSTEM

Key facts

Dexbrompheniramine is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1963. DrugCentral lists 1 molecular target, including HRH1. Recorded indications include Allergic conjunctivitis, Allergic rhinitis, Dermatographic urticaria and Influenza-like symptoms.

• Approval status: ofm (first approved 1963 by the FDA).
• Molecular targets: HRH1 (1 listed in DrugCentral).
• Indications: Allergic conjunctivitis, Allergic rhinitis, Dermatographic urticaria, Influenza-like symptoms and Itching of skin and others.
• ATC code: R06AB06 (Substituted alkylamines).
• Molecular formula: C16H19BrN2; molecular weight 319.25 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (8)

• Allergic conjunctivitis
• Allergic rhinitis
• Dermatographic urticaria
• Influenza-like symptoms
• Itching of skin
• Seasonal allergic rhinitis
• Urticaria
• Vasomotor rhinitis

Contraindications (64)

• Acidosis
• Acute abdominal pain
• Acute hepatitis
• Acute pancreatitis
• Alcohol intoxication
• Alcohol withdrawal delirium
• Alcoholism
• Angle-closure glaucoma
• Arterial thrombosis
• Arteriosclerotic vascular disease
• Asthenia
• Benign intracranial hypertension
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bradycardia
• Central nervous system depression
• Chronic heart failure
• Chronic idiopathic constipation
• Coma
• Conduction disorder of the heart
• Constipation
• Cor pulmonale
• Coronary arteriosclerosis
• Decreased respiratory function
• Dehydration
• Dependent drug abuse
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Disorder of gallbladder
• + 34 more

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1963-10-18	FDA	—	SCHERING PLOUGH

ATC classification

ATC code	Therapeutic hierarchy
R06AB06	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted alkylamines
R06AB56	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted alkylamines

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dexbrompheniramine is on its molecule page.

• Molecular formula: C₁₆H₁₉BrN₂
• Molecular weight: 319.25 g/mol
• CAS number: 132-21-8
• InChIKey: ZDIGNSYAACHWNL-HNNXBMFYSA-N
• PubChem CID: 16960

CN(C)CC[C@@H](C1=CC=C(Br)C=C1)C1=CC=CC=N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dexbrompheniramine used for?

DrugCentral lists the following indications for Dexbrompheniramine: Allergic conjunctivitis, Allergic rhinitis, Dermatographic urticaria, Influenza-like symptoms, Itching of skin, Seasonal allergic rhinitis, Urticaria and Vasomotor rhinitis.

How does Dexbrompheniramine work?

Its molecular targets in DrugCentral include HRH1 (antagonist).

When was Dexbrompheniramine first approved?

Dexbrompheniramine was first approved by the FDA in 1963.

What is the chemical formula of Dexbrompheniramine?

Dexbrompheniramine has the molecular formula C16H19BrN2 and a molecular weight of 319.25 g/mol.

Sources

• DrugCentral drug card 830 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200638 — compound record and bioactivity
• PubChem CID 16960 — chemical identifiers
• DrugBank DB00405 — drug record
• FDA UNII 75T64B71RP — substance identity
• DailyMed: FDA labels for Dexbrompheniramine — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein

How this page is built: methodology · editorial policy & corrections.