Dimetindene

DERMATOLOGICALS

Key facts

Dimetindene is a drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including HRH1, CHRM2 and CHRM3.

• Molecular targets: HRH1, CHRM2, CHRM3 and CHRM1 (6 listed in DrugCentral).
• ATC code: D04AA13 (Antihistamines for topical use).
• Molecular formula: C20H24N2; molecular weight 292.43 g/mol.

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	unknown	Ki 9.16
Muscarinic acetylcholine receptor M2	CHRM2	unknown	Ki 7.35
Muscarinic acetylcholine receptor M3	CHRM3	unknown	Ki 6.72
Muscarinic acetylcholine receptor M1	CHRM1	unknown	Ki 6.58
Muscarinic acetylcholine receptor M4	CHRM4	unknown	Ki 6.39
Muscarinic acetylcholine receptor M5	CHRM5	unknown	Ki 6.10

ATC classification

ATC code	Therapeutic hierarchy
D04AA13	DERMATOLOGICALS › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. › Antihistamines for topical use
R06AB03	RESPIRATORY SYSTEM › ANTIHISTAMINES FOR SYSTEMIC USE › ANTIHISTAMINES FOR SYSTEMIC USE › Substituted alkylamines

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Polyneuropathy	272.2
COVID-19	201.2
Drug ineffective	73.1
Renal pain	67.6
Anaemia	66.2
Leukopenia	65.8
Conjunctivitis	65.4
Dysgeusia	65.0
Vertigo	62.9
Coronavirus infection	62.5
Pyrexia	54.7
Osteochondrosis	54.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dimetindene is on its molecule page.

• Molecular formula: C₂₀H₂₄N₂
• Molecular weight: 292.43 g/mol
• CAS number: —
• InChIKey: MVMQESMQSYOVGV-UHFFFAOYSA-N
• PubChem CID: 21855

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C1=CC=CC=N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Dimetindene work?

Its molecular targets in DrugCentral include HRH1, CHRM2, CHRM3 and CHRM1.

What is the chemical formula of Dimetindene?

Dimetindene has the molecular formula C20H24N2 and a molecular weight of 292.43 g/mol.

Sources

• DrugCentral drug card 903 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1870768 — compound record and bioactivity
• PubChem CID 21855 — chemical identifiers
• DrugBank DB08801 — drug record
• FDA UNII 6LL60J9E0O — substance identity
• UniProt P35367 (HRH1) — target protein
• UniProt P08172 (CHRM2) — target protein
• UniProt P20309 (CHRM3) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P08912 (CHRM5) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.