Diethylpropion
Sympathomimetic Amine Anorectic — ALIMENTARY TRACT AND METABOLISM
Also known as: adiposon, amfepramon, amfepramone, amfepramone HCl, amfepramone hydrochloride, amphepramon, amphepramone, diethpropion, diethylpropion HCl, diethylpropion hydrochloride, diethylpropione, nopropiophenone
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Diethylpropion is an ofp drug in the Sympathomimetic Amine Anorectic class catalogued in DrugCentral. It was first approved by the FDA in 1959. DrugCentral lists 2 molecular targets, including SLC6A2 and SLC6A3. Recorded indications include Obesity.
- Approval status: ofp (first approved 1959 by the FDA).
- Drug class: Sympathomimetic Amine Anorectic.
- Molecular targets: SLC6A2 and SLC6A3 (2 listed in DrugCentral).
- Indications: Obesity.
- ATC code: A08AA03 (Centrally acting antiobesity products).
- Molecular formula: C13H19NO; molecular weight 205.30 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Obesity
Contraindications (18)
- Alcoholism
- Arteriosclerotic vascular disease
- Breastfeeding (mother)
- Chronic heart failure
- Conduction disorder of the heart
- Diabetes mellitus type 1
- Diabetes mellitus type 2
- Disorder of coronary artery
- Drug-induced psychosis
- Epilepsy
- Feeling agitated
- Glaucoma
- Heart valve disorder
- Hypertensive disorder
- Hypertensive urgency
- Hyperthyroidism
- Pulmonary hypertension
- Substance abuse
Mechanism & targets
| Established pharmacologic class | Sympathomimetic Amine Anorectic |
|---|
Molecular targets (2)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Sodium-dependent noradrenaline transporter | SLC6A2 | inhibitor | — |
| Sodium-dependent dopamine transporter | SLC6A3 | inhibitor | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1959-08-06 | FDA | — | ACTAVIS LABS UT INC |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
A08AA03 | ALIMENTARY TRACT AND METABOLISM › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › Centrally acting antiobesity products |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Diethylpropion is on its molecule page.
| Molecular formula | C13H19NO |
|---|---|
| Molecular weight | 205.30 g/mol |
| CAS number | 90-84-6 |
| InChIKey | XXEPPPIWZFICOJ-UHFFFAOYSA-N |
| PubChem CID | 7029 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Diethylpropion used for?
DrugCentral lists the following indications for Diethylpropion: Obesity.
How does Diethylpropion work?
Its molecular targets in DrugCentral include SLC6A2 (inhibitor) and SLC6A3 (inhibitor).
When was Diethylpropion first approved?
Diethylpropion was first approved by the FDA in 1959.
What drug class does Diethylpropion belong to?
Diethylpropion is in the Sympathomimetic Amine Anorectic class.
What is the chemical formula of Diethylpropion?
Diethylpropion has the molecular formula C13H19NO and a molecular weight of 205.30 g/mol.
Browse: all drugs starting with D · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 874 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1194666 — compound record and bioactivity
- PubChem CID 7029 — chemical identifiers
- DrugBank DB00937 — drug record
- FDA UNII Q94YYU22B8 — substance identity
- DailyMed: FDA labels for Diethylpropion — current prescribing information (label search)
- UniProt P23975 (SLC6A2) — target protein
- UniProt Q01959 (SLC6A3) — target protein
How this page is built: methodology · editorial policy & corrections.
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