Phentermine

Sympathomimetic Amine Anorectic — ALIMENTARY TRACT AND METABOLISM

Key facts

Phentermine is an ofp drug in the Sympathomimetic Amine Anorectic class catalogued in DrugCentral. It was first approved by the FDA in 1959. DrugCentral lists 2 molecular targets, including SLC6A3 and SLC6A2. Recorded indications include Hypotension Secondary to Spinal Anesthesia, Low blood pressure, Obesity and Prevention of Hypotension During Spinal Anesthesia.

• Approval status: ofp (first approved 1959 by the FDA).
• Drug class: Sympathomimetic Amine Anorectic.
• Molecular targets: SLC6A3 and SLC6A2 (2 listed in DrugCentral).
• Indications: Hypotension Secondary to Spinal Anesthesia, Low blood pressure, Obesity and Prevention of Hypotension During Spinal Anesthesia.
• ATC code: A08AA01 (Centrally acting antiobesity products).
• Molecular formula: C10H15N; molecular weight 149.24 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Hypotension Secondary to Spinal Anesthesia
• Low blood pressure
• Obesity
• Prevention of Hypotension During Spinal Anesthesia

Contraindications (19)

• Alcoholism
• Angina pectoris
• Arteriosclerosis obliterans
• Conduction disorder of the heart
• Diabetes mellitus type 1
• Disorder of cardiovascular system
• Edema
• Feeling agitated
• Glaucoma
• Heart valve disorder
• Hypertensive disorder
• Hypertensive urgency
• Hyperthyroidism
• Mild pre-eclampsia
• Psychotic disorder
• Pulmonary hypertension
• Secondary glaucoma
• Substance abuse
• Syncope

Mechanism & targets

• Established pharmacologic class: Sympathomimetic Amine Anorectic

Molecular targets (2)

Target	Gene	Action	Activity
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 5.80
Sodium-dependent noradrenaline transporter	SLC6A2	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1959-05-04	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A08AA01	ALIMENTARY TRACT AND METABOLISM › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › Centrally acting antiobesity products
A08AA51	ALIMENTARY TRACT AND METABOLISM › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › Centrally acting antiobesity products

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Cholecystitis chronic	181.2
Stress cardiomyopathy	105.8
Drug abuse	101.9
Dermatitis atopic	85.0
Completed suicide	81.1
Colitis ischaemic	78.3
Gallbladder disorder	76.3
Arteriospasm coronary	73.3
Emotional distress	73.0
Anxiety	57.5
Carotid artery dissection	57.1
Product dose omission issue	55.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Phentermine is on its molecule page.

• Molecular formula: C₁₀H₁₅N
• Molecular weight: 149.24 g/mol
• CAS number: 122-09-8
• InChIKey: DHHVAGZRUROJKS-UHFFFAOYSA-N
• PubChem CID: 4771

CC(C)(N)CC1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Phentermine used for?

DrugCentral lists the following indications for Phentermine: Hypotension Secondary to Spinal Anesthesia, Low blood pressure, Obesity and Prevention of Hypotension During Spinal Anesthesia.

How does Phentermine work?

Its molecular targets in DrugCentral include SLC6A3 and SLC6A2 (inhibitor).

When was Phentermine first approved?

Phentermine was first approved by the FDA in 1959.

What drug class does Phentermine belong to?

Phentermine is in the Sympathomimetic Amine Anorectic class.

What is the chemical formula of Phentermine?

Phentermine has the molecular formula C10H15N and a molecular weight of 149.24 g/mol.

Sources

• DrugCentral drug card 2140 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200912 — compound record and bioactivity
• PubChem CID 4771 — chemical identifiers
• DrugBank DB00191 — drug record
• FDA UNII C045TQL4WP — substance identity
• DailyMed: FDA labels for Phentermine — current prescribing information (label search)
• UniProt Q01959 (SLC6A3) — target protein
• UniProt P23975 (SLC6A2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.