Mazindol

ALIMENTARY TRACT AND METABOLISM

Key facts

Mazindol is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1973. DrugCentral lists 9 molecular targets, including SLC6A2, Slc6a2 and Slc6a3. Recorded indications include Obesity.

• Approval status: ofm (first approved 1973 by the FDA).
• Molecular targets: SLC6A2, Slc6a2, Slc6a3 and SLC6A3 (9 listed in DrugCentral).
• Indications: Obesity.
• ATC code: A08AA05 (Centrally acting antiobesity products).
• Molecular formula: C16H13ClN2O; molecular weight 284.74 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Obesity

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Sodium-dependent noradrenaline transporter	SLC6A2	inhibitor	Kd 9.30
Transporter	Slc6a2	unknown	Ki 9.10
Sodium-dependent dopamine transporter	Slc6a3	unknown	Kd 8.06
Sodium-dependent dopamine transporter	SLC6A3	inhibitor	Ki 8.00
Sodium-dependent dopamine transporter	Slc6a3	unknown	IC50 7.89
Sodium-dependent serotonin transporter	SLC6A4	inhibitor	Ki 7.30
Sigma non-opioid intracellular receptor 1	SIGMAR1	unknown	IC50 6.63
Sodium-dependent serotonin transporter	Slc6a4	unknown	Ki 6.61
Histamine H1 receptor	HRH1	unknown	Ki 6.22

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1973-06-14	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A08AA05	ALIMENTARY TRACT AND METABOLISM › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS › Centrally acting antiobesity products

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Mazindol is on its molecule page.

• Molecular formula: C₁₆H₁₃ClN₂O
• Molecular weight: 284.74 g/mol
• CAS number: 22232-71-9
• InChIKey: ZPXSCAKFGYXMGA-UHFFFAOYSA-N
• PubChem CID: 4020

OC1(N2CCN=C2C2=CC=CC=C12)C1=CC=C(Cl)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Mazindol used for?

DrugCentral lists the following indications for Mazindol: Obesity.

How does Mazindol work?

Its molecular targets in DrugCentral include SLC6A2 (inhibitor), Slc6a2, Slc6a3 and SLC6A3 (inhibitor).

When was Mazindol first approved?

Mazindol was first approved by the FDA in 1973.

What is the chemical formula of Mazindol?

Mazindol has the molecular formula C16H13ClN2O and a molecular weight of 284.74 g/mol.

Sources

• DrugCentral drug card 1640 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL781 — compound record and bioactivity
• PubChem CID 4020 — chemical identifiers
• DrugBank DB00579 — drug record
• FDA UNII C56709M5NH — substance identity
• DailyMed: FDA labels for Mazindol — current prescribing information (label search)
• UniProt P23975 (SLC6A2) — target protein
• UniProt Q01959 (SLC6A3) — target protein
• UniProt P31645 (SLC6A4) — target protein
• UniProt Q99720 (SIGMAR1) — target protein
• UniProt P35367 (HRH1) — target protein

How this page is built: methodology · editorial policy & corrections.