Rilmenidine

CARDIOVASCULAR SYSTEM

Key facts

Rilmenidine is a drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including Nisch, ADRA2C and ADRA2A. Recorded indications include Hypertensive disorder.

• Molecular targets: Nisch, ADRA2C, ADRA2A and ADRA2B (6 listed in DrugCentral).
• Indications: Hypertensive disorder.
• ATC code: C02AC06 (Imidazoline receptor agonists).
• Molecular formula: C10H16N2O; molecular weight 180.25 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Hypertensive disorder

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Nischarin	Nisch	unknown	Ki 7.95
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 7.90
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 7.44
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 7.37
Nischarin	NISCH	unknown	Ki 7.23
Alpha-1A adrenergic receptor	ADRA1A	unknown	Ki 5.05

ATC classification

ATC code	Therapeutic hierarchy
C02AC06	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIADRENERGIC AGENTS, CENTRALLY ACTING › Imidazoline receptor agonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Acute kidney injury	698.0
Lactic acidosis	408.1
Hyperkalaemia	307.2
Hyponatraemia	130.6
Rhabdomyolysis	105.2
Allergic reaction to excipient	99.6
Bradycardia	85.8
Isosthenuria	83.5
Hypoglycaemia	79.2
Primary hyperaldosteronism	78.4
Pemphigoid	73.8
Enterobacter pneumonia	70.8

Chemical structure

• Molecular formula: C₁₀H₁₆N₂O
• Molecular weight: 180.25 g/mol
• CAS number: 54187-04-1
• InChIKey: CQXADFVORZEARL-UHFFFAOYSA-N
• PubChem CID: 68712

C1CC1C(NC1=NCCO1)C1CC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Rilmenidine used for?

DrugCentral lists the following indications for Rilmenidine: Hypertensive disorder.

How does Rilmenidine work?

Its molecular targets in DrugCentral include Nisch, ADRA2C, ADRA2A and ADRA2B.

What is the chemical formula of Rilmenidine?

Rilmenidine has the molecular formula C10H16N2O and a molecular weight of 180.25 g/mol.

Sources

• DrugCentral drug card 2381 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL289480 — compound record and bioactivity
• PubChem CID 68712 — chemical identifiers
• DrugBank DB11738 — drug record
• FDA UNII P67IM25ID8 — substance identity
• UniProt P18825 (ADRA2C) — target protein
• UniProt P08913 (ADRA2A) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt Q9Y2I1 (NISCH) — target protein
• UniProt P35348 (ADRA1A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.