Tramazoline

RESPIRATORY SYSTEM

Key facts

Tramazoline is a drug catalogued in DrugCentral. DrugCentral lists 5 molecular targets, including Adra2b|Adra2c|Adra2a, ADRA2A and ADRA2B. Recorded indications include Allergic conjunctivitis, Allergic rhinitis, Common cold and Nasal congestion.

• Molecular targets: Adra2b|Adra2c|Adra2a, ADRA2A, ADRA2B and ADRA2C (5 listed in DrugCentral).
• Indications: Allergic conjunctivitis, Allergic rhinitis, Common cold, Nasal congestion and Nasal discharge and others.
• ATC code: R01AA09 (Sympathomimetics, plain).
• Molecular formula: C13H17N3; molecular weight 215.30 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (8)

• Allergic conjunctivitis
• Allergic rhinitis
• Common cold
• Nasal congestion
• Nasal discharge
• Seasonal allergic rhinitis
• Sneezing
• Vasomotor rhinitis

Contraindications (10)

• Angle-closure glaucoma
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Chronic idiopathic constipation
• Chronic obstructive lung disease
• Gastrointestinal obstruction
• Hypertensive disorder
• Hyperthyroidism
• Peptic ulcer
• Retention of urine

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Adrenergic receptor alpha-2	Adra2b|Adra2c|Adra2a	unknown	Ki 8.38
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 7.50
Alpha-2B adrenergic receptor	ADRA2B	unknown	Ki 6.86
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 6.56
Adrenergic receptor alpha-1	Adra1b|Adra1d|Adra1a	unknown	IC50 5.96

ATC classification

ATC code	Therapeutic hierarchy
R01AA09	RESPIRATORY SYSTEM › NASAL PREPARATIONS › DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE › Sympathomimetics, plain

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Tramazoline is on its molecule page.

• Molecular formula: C₁₃H₁₇N₃
• Molecular weight: 215.30 g/mol
• CAS number: 1082-57-1
• InChIKey: QQJLHRRUATVHED-UHFFFAOYSA-N
• PubChem CID: 5524

C1CN=C(NC2=C3CCCCC3=CC=C2)N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tramazoline used for?

DrugCentral lists the following indications for Tramazoline: Allergic conjunctivitis, Allergic rhinitis, Common cold, Nasal congestion, Nasal discharge, Seasonal allergic rhinitis, Sneezing and Vasomotor rhinitis.

How does Tramazoline work?

Its molecular targets in DrugCentral include Adra2b|Adra2c|Adra2a, ADRA2A, ADRA2B and ADRA2C.

What is the chemical formula of Tramazoline?

Tramazoline has the molecular formula C13H17N3 and a molecular weight of 215.30 g/mol.

Sources

• DrugCentral drug card 3620 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2107640 — compound record and bioactivity
• PubChem CID 5524 — chemical identifiers
• DrugBank DB13064 — drug record
• FDA UNII SLE31693IV — substance identity
• UniProt P08913 (ADRA2A) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P18825 (ADRA2C) — target protein

How this page is built: methodology · editorial policy & corrections.