Trandolapril

Angiotensin Converting Enzyme Inhibitor — CARDIOVASCULAR SYSTEM

Key facts

Trandolapril is an ofp drug in the Angiotensin Converting Enzyme Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 1996. Its mechanism of action is classified as Angiotensin-converting Enzyme Inhibitors. DrugCentral lists 1 molecular target, including ACE. Recorded indications include Chronic heart failure, Hypertensive disorder and Left ventricular cardiac dysfunction.

• Approval status: ofp (first approved 1996 by the FDA).
• Drug class: Angiotensin Converting Enzyme Inhibitor.
• Mechanism of action: Angiotensin-converting Enzyme Inhibitors.
• Molecular targets: ACE (1 listed in DrugCentral).
• Indications: Chronic heart failure, Hypertensive disorder and Left ventricular cardiac dysfunction.
• ATC code: C09AA10 (ACE inhibitors, plain).
• Molecular formula: C24H34N2O5; molecular weight 430.55 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Chronic heart failure
• Hypertensive disorder
• Left ventricular cardiac dysfunction

Off-label uses (4)

• Atrial fibrillation
• Diabetic renal disease
• Diastolic heart failure
• Nondiabetic Proteinuric Nephropathy

Contraindications (34)

• Acute cerebrovascular insufficiency
• Angioedema
• Aortic valve stenosis
• Bone marrow depression
• Bradycardia
• Cardiogenic shock
• Chronic idiopathic constipation
• Complete atrioventricular block
• Disease of liver
• Disorder of connective tissue
• Duchenne muscular dystrophy
• First Degree Atrioventricular Heart Block
• Hemodialysis with High-Flux Membrane
• Hereditary angioneurotic edema
• Hyperkalemia
• Hypertrophic cardiomyopathy
• Hyponatremia
• Immunosuppression
• Kidney disease
• Left heart failure
• Liver function tests abnormal
• Low blood pressure
• Low cardiac output syndrome
• Lown-Ganong-Levine syndrome
• Myasthenia gravis
• Neuromuscular Transmission Deficiency
• Neutropenic disorder
• Pregnancy, function
• Renal artery stenosis
• Second degree atrioventricular block
• + 4 more

Mechanism & targets

• Mechanism of action (MoA): Angiotensin-converting Enzyme Inhibitors
• Established pharmacologic class: Angiotensin Converting Enzyme Inhibitor

Molecular targets (1)

Target	Gene	Action	Activity
Angiotensin-converting enzyme	ACE	inhibitor	IC50 8.12

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1996-04-26	FDA	—	ABBVIE

ATC classification

ATC code	Therapeutic hierarchy
C09AA10	CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, PLAIN › ACE inhibitors, plain
C09BB10	CARDIOVASCULAR SYSTEM › AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM › ACE INHIBITORS, COMBINATIONS › ACE inhibitors and calcium channel blockers

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Lactic acidosis	91.0
Psychotic disorder	69.0
Oesophageal obstruction	68.5
Cough	68.0
Bezoar	51.7
Hypertensive encephalopathy	50.4
Paranoia	48.7
Substance use	48.3
Cerebellar haematoma	38.2
Hallucination, auditory	37.8
Hyperaesthesia	37.3
Arterial disorder	36.9

Chemical structure

• Molecular formula: C₂₄H₃₄N₂O₅
• Molecular weight: 430.55 g/mol
• CAS number: 87679-37-6
• InChIKey: VXFJYXUZANRPDJ-WTNASJBWSA-N
• PubChem CID: 5464097

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@@H]2C[C@H]1C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Trandolapril used for?

DrugCentral lists the following indications for Trandolapril: Chronic heart failure, Hypertensive disorder and Left ventricular cardiac dysfunction.

How does Trandolapril work?

Trandolapril is classified as Angiotensin-converting Enzyme Inhibitors; its molecular targets in DrugCentral include ACE (inhibitor).

When was Trandolapril first approved?

Trandolapril was first approved by the FDA in 1996.

What drug class does Trandolapril belong to?

Trandolapril is in the Angiotensin Converting Enzyme Inhibitor class.

What is the chemical formula of Trandolapril?

Trandolapril has the molecular formula C24H34N2O5 and a molecular weight of 430.55 g/mol.

Sources

• DrugCentral drug card 2712 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201387 — compound record and bioactivity
• PubChem CID 5464097 — chemical identifiers
• DrugBank DB00519 — drug record
• FDA UNII 1T0N3G9CRC — substance identity
• DailyMed: FDA labels for Trandolapril — current prescribing information (label search)
• UniProt P12821 (ACE) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.