Clidinium

Anticholinergic — ALIMENTARY TRACT AND METABOLISM

Key facts

Clidinium is an ofp drug in the Anticholinergic class catalogued in DrugCentral. Its mechanism of action is classified as Cholinergic Antagonists. DrugCentral lists 2 molecular targets, including CHRM3 and CHRM1. Recorded indications include Enterocolitis and Irritable bowel syndrome.

• Approval status: ofp.
• Drug class: Anticholinergic.
• Mechanism of action: Cholinergic Antagonists.
• Molecular targets: CHRM3 and CHRM1 (2 listed in DrugCentral).
• Indications: Enterocolitis and Irritable bowel syndrome.
• ATC code: A03CA02 (Synthetic anticholinergic agents in combination with psycholeptics).
• Molecular formula: C22H26NO3; molecular weight 352.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Enterocolitis
• Irritable bowel syndrome

Contraindications (49)

• Achalasia of esophagus
• Alcohol intoxication
• Angle-closure glaucoma
• Atony of colon
• Autonomic dysreflexia
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bleeding
• Brain damage
• Breastfeeding (mother)
• Chronic heart failure
• Chronic lung disease
• Complete trisomy 21 syndrome
• Depressive disorder
• Disease of liver
• Disorder of coronary artery
• Disorder of lung
• Disturbance of salivary secretion
• Drowsy
• Drug AND/OR toxin-induced diarrhea
• Gastric ulcer
• Gastrointestinal obstruction
• Glaucoma
• Hiatal hernia
• Hyperactive behavior
• Hypertensive disorder
• Hyperthyroidism
• Hypoalbuminemia
• Kidney disease
• Myasthenia gravis
• + 19 more

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Antagonists
• Established pharmacologic class: Anticholinergic

Molecular targets (2)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M3	CHRM3	antagonist	Ki 9.60
Muscarinic acetylcholine receptor M1	CHRM1	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	ROCHE

ATC classification

ATC code	Therapeutic hierarchy
A03CA02	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS › Synthetic anticholinergic agents in combination with psycholeptics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Apraxia	63.3
Perseveration	59.2
Disorientation	50.2
Hyperreflexia	41.1
Cognitive disorder	38.2
Myoclonus	34.7
Cholecystitis chronic	31.9

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Clidinium is on its molecule page.

• Molecular formula: C₂₂H₂₆NO₃
• Molecular weight: 352.45 g/mol
• CAS number: 7020-55-5
• InChIKey: HOOSGZJRQIVJSZ-UHFFFAOYSA-N
• PubChem CID: 2784

C[N+]12CCC(CC1)C(C2)OC(=O)C(O)(C1=CC=CC=C1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Clidinium used for?

DrugCentral lists the following indications for Clidinium: Enterocolitis and Irritable bowel syndrome.

How does Clidinium work?

Clidinium is classified as Cholinergic Antagonists; its molecular targets in DrugCentral include CHRM3 (antagonist) and CHRM1 (antagonist).

What drug class does Clidinium belong to?

Clidinium is in the Anticholinergic class.

What is the chemical formula of Clidinium?

Clidinium has the molecular formula C22H26NO3 and a molecular weight of 352.45 g/mol.

Sources

• DrugCentral drug card 676 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200950 — compound record and bioactivity
• PubChem CID 2784 — chemical identifiers
• DrugBank DB00771 — drug record
• FDA UNII BO76JF850N — substance identity
• DailyMed: FDA labels for Clidinium — current prescribing information (label search)
• UniProt P20309 (CHRM3) — target protein
• UniProt P11229 (CHRM1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.