Propantheline

Anticholinergic — ALIMENTARY TRACT AND METABOLISM

Key facts

Propantheline is an ofm drug in the Anticholinergic class catalogued in DrugCentral. It was first approved by the FDA in 1953. Its mechanism of action is classified as Cholinergic Antagonists. DrugCentral lists 4 molecular targets, including CHRM4, CHRM3 and CHRM1. Recorded indications include Peptic ulcer.

• Approval status: ofm (first approved 1953 by the FDA).
• Drug class: Anticholinergic.
• Mechanism of action: Cholinergic Antagonists.
• Molecular targets: CHRM4, CHRM3, CHRM1 and CHRM2 (4 listed in DrugCentral).
• Indications: Peptic ulcer.
• ATC code: A03AB05 (Synthetic anticholinergics, quaternary ammonium compounds).
• Molecular formula: C23H30NO3; molecular weight 368.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Peptic ulcer

Off-label uses (2)

• Irritable bowel syndrome
• Urinary incontinence

Contraindications (34)

• Achalasia of esophagus
• Angle-closure glaucoma
• Atony of colon
• Autonomic dysreflexia
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bleeding
• Brain damage
• Chronic heart failure
• Chronic lung disease
• Complete trisomy 21 syndrome
• Disease of liver
• Disorder of coronary artery
• Disturbance of salivary secretion
• Drowsy
• Drug AND/OR toxin-induced diarrhea
• Gastric ulcer
• Gastrointestinal obstruction
• Hiatal hernia
• Hypertensive disorder
• Hyperthyroidism
• Kidney disease
• Myasthenia gravis
• Myocardial dysfunction
• Paralytic ileus
• Peptic reflux disease
• Pyloric obstruction
• Retention of urine
• Severe chronic ulcerative colitis
• Spastic paralysis
• + 4 more

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Antagonists
• Established pharmacologic class: Anticholinergic

Molecular targets (4)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M4	CHRM4	antagonist	Ki 10.20
Muscarinic acetylcholine receptor M3	CHRM3	antagonist	Ki 10.00
Muscarinic acetylcholine receptor M1	CHRM1	antagonist	Ki 9.70
Muscarinic acetylcholine receptor M2	CHRM2	antagonist	Ki 9.50

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1953-04-02	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A03AB05	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › Synthetic anticholinergics, quaternary ammonium compounds
A03CA34	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS › Synthetic anticholinergic agents in combination with psycholeptics

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Propantheline is on its molecule page.

• Molecular formula: C₂₃H₃₀NO₃
• Molecular weight: 368.50 g/mol
• CAS number: 298-50-0
• InChIKey: VVWYOYDLCMFIEM-UHFFFAOYSA-N
• PubChem CID: 4934

CC(C)[N+](C)(CCOC(=O)C1C2=CC=CC=C2OC2=C1C=CC=C2)C(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Propantheline used for?

DrugCentral lists the following indications for Propantheline: Peptic ulcer.

How does Propantheline work?

Propantheline is classified as Cholinergic Antagonists; its molecular targets in DrugCentral include CHRM4 (antagonist), CHRM3 (antagonist), CHRM1 (antagonist) and CHRM2 (antagonist).

When was Propantheline first approved?

Propantheline was first approved by the FDA in 1953.

What drug class does Propantheline belong to?

Propantheline is in the Anticholinergic class.

What is the chemical formula of Propantheline?

Propantheline has the molecular formula C23H30NO3 and a molecular weight of 368.50 g/mol.

Sources

• DrugCentral drug card 2293 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1180725 — compound record and bioactivity
• PubChem CID 4934 — chemical identifiers
• DrugBank DB00782 — drug record
• FDA UNII 1306V2B0Q8 — substance identity
• DailyMed: FDA labels for Propantheline — current prescribing information (label search)
• UniProt P08173 (CHRM4) — target protein
• UniProt P20309 (CHRM3) — target protein
• UniProt P11229 (CHRM1) — target protein
• UniProt P08172 (CHRM2) — target protein

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