Isopropamide

ALIMENTARY TRACT AND METABOLISM

Key facts

Isopropamide is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1957. DrugCentral lists 2 molecular targets, including CHRM1 and CHRM3. Recorded indications include Peptic ulcer.

• Approval status: ofm (first approved 1957 by the FDA).
• Molecular targets: CHRM1 and CHRM3 (2 listed in DrugCentral).
• Indications: Peptic ulcer.
• ATC code: A03AB09 (Synthetic anticholinergics, quaternary ammonium compounds).
• Molecular formula: C23H33N2O; molecular weight 353.53 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Peptic ulcer

Contraindications (69)

• Achalasia of esophagus
• Acute disease of cardiovascular system
• Alcoholism
• Anemia
• Angina pectoris
• Angle-closure glaucoma
• At risk for aspiration
• Atony of colon
• Autonomic dysreflexia
• Benign prostatic hyperplasia
• Bladder outflow obstruction
• Bleeding
• Bradycardia
• Brain damage
• Breastfeeding (mother)
• Carcinoma of female breast
• Chronic disease of respiratory system
• Chronic heart failure
• Chronic lung disease
• Coma
• Complete trisomy 21 syndrome
• Conduction disorder of the heart
• Congenital long QT syndrome
• Disease of liver
• Disorder of coronary artery
• Disturbance of salivary secretion
• Drowsy
• Drug AND/OR toxin-induced diarrhea
• Epilepsy
• Extrapyramidal disease
• + 39 more

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M1	CHRM1	antagonist	—
Muscarinic acetylcholine receptor M3	CHRM3	antagonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1957-10-09	FDA	—	GLAXOSMITHKLINE

ATC classification

ATC code	Therapeutic hierarchy
A03AB09	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › Synthetic anticholinergics, quaternary ammonium compounds
A03CA01	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS › Synthetic anticholinergic agents in combination with psycholeptics

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Isopropamide is on its molecule page.

• Molecular formula: C₂₃H₃₃N₂O
• Molecular weight: 353.53 g/mol
• CAS number: 7492-32-2
• InChIKey: JTPUMZTWMWIVPA-UHFFFAOYSA-O
• PubChem CID: 3775

CC(C)[N+](C)(CCC(C(N)=O)(C1=CC=CC=C1)C1=CC=CC=C1)C(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Isopropamide used for?

DrugCentral lists the following indications for Isopropamide: Peptic ulcer.

How does Isopropamide work?

Its molecular targets in DrugCentral include CHRM1 (antagonist) and CHRM3 (antagonist).

When was Isopropamide first approved?

Isopropamide was first approved by the FDA in 1957.

What is the chemical formula of Isopropamide?

Isopropamide has the molecular formula C23H33N2O and a molecular weight of 353.53 g/mol.

Sources

• DrugCentral drug card 1500 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200347 — compound record and bioactivity
• PubChem CID 3775 — chemical identifiers
• DrugBank DB01625 — drug record
• FDA UNII 8B9I31H724 — substance identity
• DailyMed: FDA labels for Isopropamide — current prescribing information (label search)
• UniProt P11229 (CHRM1) — target protein
• UniProt P20309 (CHRM3) — target protein

How this page is built: methodology · editorial policy & corrections.