Idebenone

NERVOUS SYSTEM

Key facts

Idebenone is a drug catalogued in DrugCentral. It was first approved by the EMA in 2015. DrugCentral lists 5 molecular targets, including CYP2C19, Sirt2 and CYP2D6. Recorded indications include Leber's optic atrophy.

• Molecular targets: CYP2C19, Sirt2, CYP2D6 and CYP2C9 (5 listed in DrugCentral).
• Indications: Leber's optic atrophy.
• ATC code: N06BX13 (Other psychostimulants and nootropics).
• Molecular formula: C19H30O5; molecular weight 338.44 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Leber's optic atrophy

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Cytochrome P450 2C19	CYP2C19	unknown	IC50 6.10
NAD-dependent protein deacetylase	Sirt2	unknown	IC50 5.72
Cytochrome P450 2D6	CYP2D6	unknown	IC50 5.52
Cytochrome P450 2C9	CYP2C9	unknown	IC50 5.30
Cytochrome P450 3A4	CYP3A4	unknown	IC50 5.16

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2015-09-08	EMA	—	—	Yes

ATC classification

ATC code	Therapeutic hierarchy
N06BX13	NERVOUS SYSTEM › PSYCHOANALEPTICS › PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS › Other psychostimulants and nootropics

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Idebenone is on its molecule page.

• Molecular formula: C₁₉H₃₀O₅
• Molecular weight: 338.44 g/mol
• CAS number: 58186-27-9
• InChIKey: JGPMMRGNQUBGND-UHFFFAOYSA-N
• PubChem CID: 3686

COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Idebenone used for?

DrugCentral lists the following indications for Idebenone: Leber's optic atrophy.

How does Idebenone work?

Its molecular targets in DrugCentral include CYP2C19, Sirt2, CYP2D6 and CYP2C9.

When was Idebenone first approved?

Idebenone was first approved by the EMA in 2015.

What is the chemical formula of Idebenone?

Idebenone has the molecular formula C19H30O5 and a molecular weight of 338.44 g/mol.

Sources

• DrugCentral drug card 1416 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL252556 — compound record and bioactivity
• PubChem CID 3686 — chemical identifiers
• DrugBank DB09081 — drug record
• FDA UNII HB6PN45W4J — substance identity
• UniProt P33261 (CYP2C19) — target protein
• UniProt P10635 (CYP2D6) — target protein
• UniProt P11712 (CYP2C9) — target protein
• UniProt P08684 (CYP3A4) — target protein

How this page is built: methodology · editorial policy & corrections.