Solifenacin

Cholinergic Muscarinic Antagonist — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Solifenacin is an ofp drug in the Cholinergic Muscarinic Antagonist class catalogued in DrugCentral. It was first approved by the FDA in 2004. Its mechanism of action is classified as Cholinergic Muscarinic Antagonists. DrugCentral lists 8 molecular targets, including Chrm1, Chrm3 and CHRM1. Recorded indications include Bladder muscle dysfunction - overactive, Increased Urinary Frequency, Urge incontinence of urine and Urgent desire to urinate.

• Approval status: ofp (first approved 2004 by the FDA).
• Drug class: Cholinergic Muscarinic Antagonist.
• Mechanism of action: Cholinergic Muscarinic Antagonists.
• Molecular targets: Chrm1, Chrm3, CHRM1 and CHRM5 (8 listed in DrugCentral).
• Indications: Bladder muscle dysfunction - overactive, Increased Urinary Frequency, Urge incontinence of urine and Urgent desire to urinate.
• ATC code: G04BD08 (Drugs for urinary frequency and incontinence).
• Molecular formula: C23H26N2O2; molecular weight 362.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (4)

• Bladder muscle dysfunction - overactive
• Increased Urinary Frequency
• Urge incontinence of urine
• Urgent desire to urinate

Contraindications (12)

• Acute nephropathy
• Angle-closure glaucoma
• Bladder outflow obstruction
• Congenital long QT syndrome
• Disease of liver
• Gastric retention
• Gastrointestinal hypomotility
• Gastrointestinal obstruction
• Hepatic failure
• Prolonged QT interval
• Retention of urine
• Torsades de pointes

Mechanism & targets

• Mechanism of action (MoA): Cholinergic Muscarinic Antagonists
• Established pharmacologic class: Cholinergic Muscarinic Antagonist

Molecular targets (8)

Target	Gene	Action	Activity
Muscarinic acetylcholine receptor M1	Chrm1	unknown	Ki 8.00
Muscarinic acetylcholine receptor M3	Chrm3	unknown	Ki 8.00
Muscarinic acetylcholine receptor M1	CHRM1	unknown	IC50 7.20
Muscarinic acetylcholine receptor M5	CHRM5	antagonist	Ki 7.20
Muscarinic acetylcholine receptor M2	Chrm2	unknown	Ki 6.92
Muscarinic acetylcholine receptor M3	CHRM3	antagonist	IC50 6.88
Muscarinic acetylcholine receptor M4	CHRM4	antagonist	Ki 6.80
Muscarinic acetylcholine receptor M2	CHRM2	antagonist	IC50 6.24

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2004-11-19	FDA	—	ASTELLAS

ATC classification

ATC code	Therapeutic hierarchy
G04BD08	GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › UROLOGICALS › Drugs for urinary frequency and incontinence
G04CA53	GENITO URINARY SYSTEM AND SEX HORMONES › UROLOGICALS › DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY › Alpha-adrenoreceptor antagonists

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Urinary retention	298.4
Fall	271.9
Dry mouth	198.7
Urinary incontinence	181.3
Urinary tract infection	180.0
Cerebral hypoperfusion	162.1
Multiple sclerosis relapse	160.7
Constipation	158.6
Dementia	134.7
Systemic lupus erythematosus	118.8
Vision blurred	106.8
Dysuria	100.9

Chemical structure

• Molecular formula: C₂₃H₂₆N₂O₂
• Molecular weight: 362.47 g/mol
• CAS number: 242478-37-1
• InChIKey: FBOUYBDGKBSUES-VXKWHMMOSA-N
• PubChem CID: 154059

O=C(O[C@H]1CN2CCC1CC2)N1CCC2=CC=CC=C2[C@@H]1C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Solifenacin used for?

DrugCentral lists the following indications for Solifenacin: Bladder muscle dysfunction - overactive, Increased Urinary Frequency, Urge incontinence of urine and Urgent desire to urinate.

How does Solifenacin work?

Solifenacin is classified as Cholinergic Muscarinic Antagonists; its molecular targets in DrugCentral include Chrm1, Chrm3, CHRM1 and CHRM5 (antagonist).

When was Solifenacin first approved?

Solifenacin was first approved by the FDA in 2004.

What drug class does Solifenacin belong to?

Solifenacin is in the Cholinergic Muscarinic Antagonist class.

What is the chemical formula of Solifenacin?

Solifenacin has the molecular formula C23H26N2O2 and a molecular weight of 362.47 g/mol.

Sources

• DrugCentral drug card 2457 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200803 — compound record and bioactivity
• PubChem CID 154059 — chemical identifiers
• DrugBank DB01591 — drug record
• FDA UNII A8910SQJ1U — substance identity
• DailyMed: FDA labels for Solifenacin — current prescribing information (label search)
• UniProt P11229 (CHRM1) — target protein
• UniProt P08912 (CHRM5) — target protein
• UniProt P20309 (CHRM3) — target protein
• UniProt P08173 (CHRM4) — target protein
• UniProt P08172 (CHRM2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.