Norgestimate

Progestin — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Norgestimate is an ofp drug in the Progestin class catalogued in DrugCentral. It was first approved by the FDA in 1989. DrugCentral lists 3 molecular targets, including TRPC3, TRPC6 and PGR. Recorded indications include Acne vulgaris, Atrophic vaginitis, Atrophic vulva and Contraception.

• Approval status: ofp (first approved 1989 by the FDA).
• Drug class: Progestin.
• Molecular targets: TRPC3, TRPC6 and PGR (3 listed in DrugCentral).
• Indications: Acne vulgaris, Atrophic vaginitis, Atrophic vulva, Contraception and Menopausal flushing and others.
• ATC code: G03AA11 (Progestogens and estrogens, fixed combinations).
• Molecular formula: C23H31NO3; molecular weight 369.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (6)

• Acne vulgaris
• Atrophic vaginitis
• Atrophic vulva
• Contraception
• Menopausal flushing
• Postmenopausal osteoporosis

Off-label uses (6)

• Abnormal uterine bleeding unrelated to menstrual cycle
• Amenorrhea
• Dysmenorrhea
• Female hypogonadism syndrome
• Menorrhagia
• Polycystic ovaries

Contraindications (65)

• Angina pectoris
• Asthma
• Bed-ridden
• Benign mammary dysplasia
• Body fluid retention
• Breast lump
• Carcinoma of female breast
• Cardiovascular event risk
• Cerebrovascular accident
• Chloasma
• Cholestasis of pregnancy
• Chorea
• Chronic heart failure
• Deep venous thrombosis
• Dementia
• Depressive disorder
• Diabetes mellitus
• Diplopia
• Disease of liver
• Disorder of coronary artery
• Disorder of gallbladder
• Endometrial carcinoma
• Endometriosis
• Epilepsy
• Estrogen receptor positive tumor
• Family history of malignant neoplasm of breast
• Functional visual loss
• Heart valve disorder
• Hepatic porphyria
• Humoral hypercalcemia of malignancy
• + 35 more

Mechanism & targets

• Established pharmacologic class: Progestin

Molecular targets (3)

Target	Gene	Action	Activity
Short transient receptor potential channel 3	TRPC3	blocker	Ki 5.52
Short transient receptor potential channel 6	TRPC6	blocker	IC50 5.28
Progesterone receptor	PGR	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1989-12-29	FDA	—	JANSSEN PHARMS

ATC classification

ATC code	Therapeutic hierarchy
G03AA11	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, fixed combinations
G03AB09	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE › Progestogens and estrogens, sequential preparations
G03FA13	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS AND ESTROGENS IN COMBINATION › Progestogens and estrogens, fixed combinations

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Norgestimate is on its molecule page.

• Molecular formula: C₂₃H₃₁NO₃
• Molecular weight: 369.50 g/mol
• CAS number: —
• InChIKey: KIQQMECNKUGGKA-NMYWJIRASA-N
• PubChem CID: 6540478

CC[C@]12CC[C@H]3[C@@H](CCC4=C\C(CC[C@H]34)=N\O)[C@@H]1CC[C@@]2(OC(C)=O)C#C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Norgestimate used for?

DrugCentral lists the following indications for Norgestimate: Acne vulgaris, Atrophic vaginitis, Atrophic vulva, Contraception, Menopausal flushing and Postmenopausal osteoporosis.

How does Norgestimate work?

Its molecular targets in DrugCentral include TRPC3 (blocker), TRPC6 (blocker) and PGR (agonist).

When was Norgestimate first approved?

Norgestimate was first approved by the FDA in 1989.

What drug class does Norgestimate belong to?

Norgestimate is in the Progestin class.

What is the chemical formula of Norgestimate?

Norgestimate has the molecular formula C23H31NO3 and a molecular weight of 369.50 g/mol.

Sources

• DrugCentral drug card 1968 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200934 — compound record and bioactivity
• PubChem CID 6540478 — chemical identifiers
• DrugBank DB00957 — drug record
• FDA UNII C291HFX4DY — substance identity
• DailyMed: FDA labels for Norgestimate — current prescribing information (label search)
• UniProt Q13507 (TRPC3) — target protein
• UniProt Q9Y210 (TRPC6) — target protein
• UniProt P06401 (PGR) — target protein

How this page is built: methodology · editorial policy & corrections.