Dichlorphenamide

Carbonic Anhydrase Inhibitor — SENSORY ORGANS

Key facts

Dichlorphenamide is an ofp drug in the Carbonic Anhydrase Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 1958. Its mechanism of action is classified as Carbonic Anhydrase Inhibitors. DrugCentral lists 30 molecular targets, including CA1, Carbonate dehydratase and CA5B. Recorded indications include Angle-closure glaucoma, Open-angle glaucoma and Secondary glaucoma.

• Approval status: ofp (first approved 1958 by the FDA).
• Drug class: Carbonic Anhydrase Inhibitor.
• Mechanism of action: Carbonic Anhydrase Inhibitors.
• Molecular targets: CA1, Carbonate dehydratase, CA5B and CA13 (30 listed in DrugCentral).
• Indications: Angle-closure glaucoma, Open-angle glaucoma and Secondary glaucoma.
• ATC code: S01EC02 (Carbonic anhydrase inhibitors).
• Molecular formula: C6H6Cl2N2O4S2; molecular weight 305.16 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Angle-closure glaucoma
• Open-angle glaucoma
• Secondary glaucoma

Off-label uses (1)

• Malignant glaucoma

Contraindications (17)

• Acute nephropathy
• Decreased respiratory function
• Diabetes mellitus type 1
• Diabetes mellitus type 2
• Disease of blood AND/OR blood-forming organ
• Disease of liver
• Disorder of electrolytes
• Gout
• Hepatic failure
• Hyperkalemia
• Hyponatremia
• Kidney disease
• Metabolic acidosis, normal anion gap, acidifying salts
• Primary adrenocortical insufficiency
• Recurrent Calcium Renal Calculi
• Renal tubular acidosis
• Respiratory acidosis

Mechanism & targets

• Mechanism of action (MoA): Carbonic Anhydrase Inhibitors
• Established pharmacologic class: Carbonic Anhydrase Inhibitor

Molecular targets (30)

Target	Gene	Action	Activity
Carbonic anhydrase 1	CA1	inhibitor	IC50 8.30
Carbonate dehydratase	—	unknown	Ki 8.07
Carbonic anhydrase 5B, mitochondrial	CA5B	inhibitor	Ki 7.68
Carbonic anhydrase 13	CA13	unknown	Ki 7.64
Carbonic anhydrase 13	Ca13	unknown	Ki 7.64
Carbonic anhydrase, alpha family	—	unknown	Ki 7.61
Carbonic anhydrase 7	CA7	inhibitor	Ki 7.58
Carbonic anhydrase 2	CA2	inhibitor	Ki 7.42
Carbonic anhydrase	NCE103	unknown	Ki 7.42
Carbonic anhydrase 9	CA9	inhibitor	Ki 7.30
Carbonic anhydrase 12	CA12	inhibitor	Ki 7.30
Astrosclerin-3	—	unknown	Ki 7.21
Carbonic anhydrase	CA2	unknown	Ki 7.10
Carbonic anhydrase 6	CA6	unknown	Ki 7.10
Carbonic anhydrase 4	CA4	inhibitor	Ki 7.02
Carbonic anhydrase 15	Ca15	unknown	Ki 7.02
Carbonic anhydrase	NCE103	unknown	Ki 6.99
Carbonic anhydrase	—	unknown	Ki 6.95
Carbonic anhydrase	—	unknown	Ki 6.82
Carbonic anhydrase 14	CA14	unknown	Ki 6.46

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1958-07-22	FDA	—	—	Yes

ATC classification

ATC code	Therapeutic hierarchy
S01EC02	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIGLAUCOMA PREPARATIONS AND MIOTICS › Carbonic anhydrase inhibitors

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Paraesthesia	342.3
Disease recurrence	335.0
Wrong technique in product usage process	256.3
Muscular weakness	144.0
Blood potassium decreased	138.8
Feeling abnormal	135.9
Dysgeusia	115.0
Confusional state	60.8
Fatigue	52.5
Asthenia	45.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dichlorphenamide is on its molecule page.

• Molecular formula: C₆H₆Cl₂N₂O₄S₂
• Molecular weight: 305.16 g/mol
• CAS number: —
• InChIKey: GJQPMPFPNINLKP-UHFFFAOYSA-N
• PubChem CID: 3038

NS(=O)(=O)C1=CC(Cl)=C(Cl)C(=C1)S(N)(=O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dichlorphenamide used for?

DrugCentral lists the following indications for Dichlorphenamide: Angle-closure glaucoma, Open-angle glaucoma and Secondary glaucoma.

How does Dichlorphenamide work?

Dichlorphenamide is classified as Carbonic Anhydrase Inhibitors; its molecular targets in DrugCentral include CA1 (inhibitor), Carbonate dehydratase, CA5B (inhibitor) and CA13.

When was Dichlorphenamide first approved?

Dichlorphenamide was first approved by the FDA in 1958.

What drug class does Dichlorphenamide belong to?

Dichlorphenamide is in the Carbonic Anhydrase Inhibitor class.

What is the chemical formula of Dichlorphenamide?

Dichlorphenamide has the molecular formula C6H6Cl2N2O4S2 and a molecular weight of 305.16 g/mol.

Sources

• DrugCentral drug card 864 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL17 — compound record and bioactivity
• PubChem CID 3038 — chemical identifiers
• DrugBank DB01144 — drug record
• FDA UNII VVJ6673MHY — substance identity
• DailyMed: FDA labels for Dichlorphenamide — current prescribing information (label search)
• UniProt P00915 (CA1) — target protein
• UniProt Q9Y2D0 (CA5B) — target protein
• UniProt Q8N1Q1 (CA13) — target protein
• UniProt P43166 (CA7) — target protein
• UniProt P00918 (CA2) — target protein
• UniProt Q16790 (CA9) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.