Terguride

GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Terguride is a drug catalogued in DrugCentral. DrugCentral lists 22 molecular targets, including ADRA2A, ADRA2B and DRD2. Recorded indications include Chronic thromboembolic pulmonary hypertension and Pulmonary arterial hypertension.

• Molecular targets: ADRA2A, ADRA2B, DRD2 and ADRA2C (22 listed in DrugCentral).
• Indications: Chronic thromboembolic pulmonary hypertension and Pulmonary arterial hypertension.
• ATC code: G02CB06 (Prolactine inhibitors).
• Molecular formula: C20H28N4O; molecular weight 340.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Chronic thromboembolic pulmonary hypertension
• Pulmonary arterial hypertension

Mechanism & targets

Molecular targets (22)

Target	Gene	Action	Activity
Alpha-2A adrenergic receptor	ADRA2A	antagonist	Ki 9.50
Alpha-2B adrenergic receptor	ADRA2B	antagonist	Ki 9.40
D(2) dopamine receptor	DRD2	agonist	Ki 9.10
Alpha-2C adrenergic receptor	ADRA2C	antagonist	Ki 9.10
D(3) dopamine receptor	DRD3	agonist	Ki 9.00
5-hydroxytryptamine receptor 1A	HTR1A	agonist	Ki 8.50
Alpha-1A adrenergic receptor	ADRA1A	antagonist	Ki 8.50
Alpha-1D adrenergic receptor	ADRA1D	unknown	Ki 8.41
D(2) dopamine receptor	Drd2	unknown	IC50 8.40
5-hydroxytryptamine receptor 2A	HTR2A	agonist	Ki 8.30
5-hydroxytryptamine receptor 2B	HTR2B	antagonist	Ki 8.20
D(4) dopamine receptor	DRD4	antagonist	Ki 8.10
5-hydroxytryptamine receptor 1D	HTR1D	agonist	Ki 7.80
Beta-2 adrenergic receptor	ADRB2	unknown	Ki 7.70
D(1B) dopamine receptor	DRD5	unknown	Ki 7.63
5-hydroxytryptamine receptor 1A	Htr1a	unknown	IC50 7.60
D(1A) dopamine receptor	DRD1	unknown	Ki 7.55
Alpha-1B adrenergic receptor	ADRA1B	unknown	Ki 7.46
5-hydroxytryptamine receptor 2C	HTR2C	antagonist	Ki 7.30
D(1A) dopamine receptor	Drd1	unknown	IC50 7.16

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	PMDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
G02CB06	GENITO URINARY SYSTEM AND SEX HORMONES › OTHER GYNECOLOGICALS › OTHER GYNECOLOGICALS › Prolactine inhibitors

Chemical structure

• Molecular formula: C₂₀H₂₈N₄O
• Molecular weight: 340.47 g/mol
• CAS number: —
• InChIKey: JOAHPSVPXZTVEP-YXJHDRRASA-N
• PubChem CID: 443951

CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](CC3=CNC4=C3C2=CC=C4)N(C)C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Terguride used for?

DrugCentral lists the following indications for Terguride: Chronic thromboembolic pulmonary hypertension and Pulmonary arterial hypertension.

How does Terguride work?

Its molecular targets in DrugCentral include ADRA2A (antagonist), ADRA2B (antagonist), DRD2 (agonist) and ADRA2C (antagonist).

What is the chemical formula of Terguride?

Terguride has the molecular formula C20H28N4O and a molecular weight of 340.47 g/mol.

Sources

• DrugCentral drug card 2601 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL73151 — compound record and bioactivity
• PubChem CID 443951 — chemical identifiers
• DrugBank DB13399 — drug record
• FDA UNII 21OJT43Q88 — substance identity
• UniProt P08913 (ADRA2A) — target protein
• UniProt P18089 (ADRA2B) — target protein
• UniProt P14416 (DRD2) — target protein
• UniProt P18825 (ADRA2C) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P08908 (HTR1A) — target protein

How this page is built: methodology · editorial policy & corrections.